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Showing 1 to 20 of 42 for “"RNR"”.
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Viengrandines mažąsias RNR modifikuojančių gyvūnų Hen1 metiltransferazių taikymas RNR žymėjimui ir sekoskaitai /
Animal Hen1 methyltransferases are composed of the N-terminal methyltransferase domain and the variable-length C-terminal region, and catalyze the S-adenosyl-L-methionine (AdoMet) dependent methylation of the 2'-O-ribose of the 3'-terminal nucleotide in a subset of small non-coding RNAs. This …
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From the End to the Middle: Regulation of Telomere Length and Kinetochore Assembly by the RNR Inhibitor SML1
… reduction by the Ribonucleotide reductase (RNR) enzyme is the sole method of production. Hence, RNR activitity is highly regulated via allosteric control, transcriptional control, differential localization of subunits, and direct inhibition of the large subunit, Rnr1, by Sml1. Loss of RNR …
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cDNA Cloning and Gene Characterization of Large and Small Subunits of Ribonucleotide Reductase in Soybean
Ribonucleotide reductase (RNR) reduces four ribonucleoside diphosphates to corresponding deoxyribonucleoside diphosphates, which are transformed into deoxyribonucleoside triphosphates, substrates for DNA polymerase. By controlling the supply and balance of deoxyribonucleoside diphosphates, RNR …
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Structural and biochemical investigations into the Neisseria gonorrhoeae ribonucleotide reductase
Ribonucleotide reductase (RNR) is the only known enzyme that converts ribonucleotide substrates to their deoxyribonucleotide products necessary for DNA synthesis and repair. For class Ia RNRs, this chemically-difficult process is tightly regulated at many levels including through allosteric …
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Record and deterministic replay of parallel programs on multiprocessors
Record and deterministic Replay (RnR) is a primitive with many proposed applications in computer systems, including debugging, security and fault tolerance. RnR is typically a two phase process: in the first phase (record) enough information about an execution is logged which is then used in the …
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Mechanistic studies of the radical transport pathway in aminotyrosine-substituted class Ia ribonucleotide reductase
Ribonucleotide reductase (RNR) catalyzes the reduction of nucleotides to 2'- deoxynucleotides. The focus of this thesis is the F coli class la RNR, which is comprised of two homodimeric subunits, [alpha]2 and [beta]2, forming an active [alpha]2[beta]2 complex. The [beta]2 subunit harbors the stable …
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Investigations of the inhibition mechanisms of human ribonucleotide reductase by gemcitabine-5'-diphosphate and saccharomyces cerevisiae ribonucleotide reductase by Sml1
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides supplying the dNTPs required for DNA replication and DNA repair. Class I RNRs require two subunits ([alpha] and [beta]) for activity. The [alpha] subunit binds the substrates and the allosteric effectors …
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Structural and functional investigations of mechanisms of iron-utilizing enzymes
… utilizing enzyme: ribonucleotide reductase (RNR), and efforts to elucidate the radical based mechanism of isonitrile formation by an mononuclear nonheme iron(II) α-ketoglutarate dependent dioxygenase, ScoE. The first part of this thesis focuses on mononuclear nonheme iron(II) α-ketoglutarate …
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Structural investigations of class la ribonucleotide reductases by electron microscopy
Ribonucleotide reductase (RNR) catalyzes the reduction of nucleotides to their 2'-deoxynucleotide counterparts. The class la RNR from Escherichia coli is composed of two homodimeric subunits [alpha]2 and [beta]2 that form an [alpha]2[beta]2 complex to perform nucleotide reduction. Chemistry is …
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Discovery and investigation of the novel overall activity allosteric regulation of the Bacillus subtilis class Ib ribonucleotide reductase
Ribonucleotide reductases (RNRs) catalyze the reduction of nucleotides to 2'-deoxynucleotides in all organisms. Class lb RNRs consist of two subunits: a houses the catalytic and allosteric effector binding sites, and p houses a catalytically essential dimanganic-tyrosyl radical (Mn(III)2-Y*). The …
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Structural studies of allosteric regulation in the class Ia Ribonucleotide reductase from Escherichia coli
Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, the building blocks for DNA replication and repair. The E. coli class Ia enzyme requires two subunits to catalyze the radical-based reduction reaction. [beta]2 houses a diferric-tyrosyl radical cofactor and [alpha]2 …
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Defining the active form of ribonucleotide reductase from Saccharomyces cerevisiae in vitro and in vivo
Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Saccharomyces cerevisiae RNR is a class I RNR composed of a dimeric large subunit (RI), containing the active site and allosteric effector sites, and a dimeric small subunit (R2) which houses the …
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Mechanistic investigations of class III anaerobic ribonucleotide reductases
Ribonucleotide reductases (RNRs) catalyze nucleotide reduction via complex radical chemistry, providing deoxynucleotides for DNA synthesis in all domains of life. The focus of this thesis is the class III RNR, found in anaerobic bacteria and archaea, which uses an O₂-sensitive glycyl radical …
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A Meta-Analysis of Intimate Partner Violence Treatment Programs: The Role of Risk-Need-Responsivity in Treatment Effectiveness
… towards adhering to the Risk-Need-Responsivity (RNR) framework, ITPs have done so in a more limited manner.</p> <p>The conflicting research regarding ITP effectiveness make it an ideal topic to be assessed with meta-analytic methods. The current dissertation relied on a meta-analytic approach to …
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Mechanistic studies of proton-coupled electron transfer in aminotyrosine- and fluorotyrosine- substituted class Ia Ribonucleotide reductase
Ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to 2'- deoxynucleotides in all organisms. The class Ia RNR from Escherichia coli is active as an a2p2 complex and utilizes an unprecedented mechanism of reversible proton-coupled electron transfer (PCET) to propagate a stable …
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Mechanistic studies of the Class I ribonucleotide reductase from Escherichia coli
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides, providing the monomeric precursors required for DNA replication and repair. The class I RNRs are found in many bacteria, DNA viruses, and all eukaryotes including humans, and are composed of two homodimeric …
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Investigation of the mechanism of radical propagation in E. coli ribonucleotide reductase by site-specific incorporation of unnatural amino acids
Inside the cell, ribonucleotide reductases (RNRs) are responsible for the conversion of nucleotides to 2'-deoxynucleotides, an essential step in DNA biosynthesis and repair. The E. coli RNR is the best studied RNR to date and consists of two protein subunits, a2 and P2. a2 is the site of nucleotide …
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Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse
… upregulation of ribonucleotide reductase (RNR) subunit M2 (RRM2) in high-risk HB. RNR is the sole enzymatic complex in mammal cells that converts ribonucleotides to deoxyribonucleotides and plays a critical role in regulating cell division and DNA repair. We found standard chemotherapy …
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Mechanistic investigations of the radical transport pathway in fluorotyrosine-substituted class Ia ribonucleotide reductases
Ribonucleotide reductase (RNR) catalyzes the reduction of nucleotides to 2'- deoxynucleotides, providing the monomeric precursors for DNA replication and repair. The focus of this thesis is on the E. coli class la RNR that is composed of two homodimeric subunits ([alpha]a2 and [beta]2), which form …
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