Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RNF8"”.
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TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
… stem cells (GSCs). The E3 ubiquitin ligase RNF8, an established DNA damage response factor, has been implicated in spindle assembly checkpoint (SAC) but its exact role remains unknown. Using RNF8 proximity proteomics, we find that RNF8 interacts with MAD2 and CAMK2D via its RING and FHA …
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Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
… DNA DSBs, the E3 ligase Ring finger protein 8 (Rnf8) orchestrates the assembly of components of homologous recombination (HR) and nonhomologous end joining (NHEJ) repair machineries into DSB-induced foci. To examine the in vivo functions of Rnf8 during mammalian development and determine the …
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Two Redundant Ubiquitin-dependent Pathways of BRCA1 Localization to DNA Damage Sites
… to DNA damage sites. I show that that RNF8 E3 ligase acts upstream of both the RAP80- and RING-dependent activities whereas RNF168 acts uniquely upstream of the RING domain. BRCA1 RING mutations that do not impact BARD1 interaction, such as the E2-binding deficient I26A mutation, …
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Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks
… manner by Ube2S/Ube2C E2 conjugating and RNF8 E3 ligase enzymes and deubiquitinated by OTUD7B (Cezanne) enzyme. I further showed that histones H2A and H2A.X is modified with Lys11-linked polyubiquitination in a DNA damage-dependent manner that is essential for inhibiting transcriptional …