Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"RNF31"”.
-
Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… two pathways. First, I investigated the role of RNF31 in mouse development with RNF31 knockout mouse. RNF31 deletion resulted in embryonic lethality of mouse around 8.5 days. Second, I examined the direct regulation of apoptosis by linear ubiquitination and RNF31. RNF31 inhibited TNF-α induced …
-
Age related memory loss and the role of the ubiquitin proteasome system
… to learning. CRISPR-dCas9 manipulation of Rnf31 levels to increase linear polyubiquitination in the aged hippocampus did not improve memory. However, it enhanced memory in young animals. These findings suggest that more processes are dysregulated in the aging brain, and further research …