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Showing 1 to 20 of 20 for “"RND"”.
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Phylogeny of the Resistance-Nodulation-Cell Division (RND) Superfamily
… the Resistance-Nodulation-Cell Division (RND) superfamily’s evolution and points of divergence. Several members of the superfamily are involved in both the acquisition and intrinsic resistance to antibiotics despite origins that are ubiquitous and ancient compared to modern-day antibiotic …
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Cloning and characterization of AdeMNO RND efflux pump of Acinetobacter baumannii
… the role of Resistance-Nodulation-cell Division (RND) efflux pumps in the antibiotic resistance mechanism of A. baumannii. Expression of six different RND pumps was analyzed in clinical isolates of A. baumannii. A novel RND family pump, AdeMNO, was found to be present in a majority of isolates. …
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Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus
The RND superfamily of efflux pumps plays vital roles in the intrinsic defence mechanisms of bacterial pathogens. The staphylococci have two genes encoding RND transporters; farE, which promotes efflux of antimicrobial fatty acids, and an uncharacterized gene we have named femT. Although RND pumps …
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Computational Study on MFP MexA in MexAB-OprM and RND transporter AcrB in AcrAB-TolC Efflux Pumps
… of the Resistance Nodulation-cell Division (RND) superfamily are particularly relevant for the occurrence of MDR. These machineries are composed of a homotrimeric inner membrane drug/proton RND antiporter, a homotrimeric outer membrane factor (OMF), and an undetermined number of Membrane …
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Molecular Rationale Behind the Differential Substrate Specificity of Homologous RND Transporters in E. coli and P. aeruginosa
… (MDR). Resistance-Nodulation-Division (RND) transporters like AcrB and AcrD in Escherichia coli, and MexB and MexY in Pseudomonas aeruginosa are the most prominent multi-component drug efflux pumps exporting a wide range of substrates ranging from lipophilic to amphiphilic molecules. …
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Impact of environmental conditions on expression levels of resistance-nodulation-division (RND) efflux pumps and outer membrane porins in Acinetobacter baumannii
… such as Resistance-Nodulation-Cell Division (RND) efflux pumps and outer membrane proteins, is regarded to be amongst the most important strategies in the arsenal of this pathogen. Despite considerable efforts being dedicated in the attempt to understand the underlying mechanisms in the …
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Characterization of NfxB and PA4596, Two Repressors of the mexCD-oprJ Operon Encoding an RND-Type Multidrug Efflux Pump in Pseudomonas aeruginosa
MexCD-OprJ is an RND-type multidrug efflux pump present in P. aeruginosa and is capable of exporting, and as such providing resistance to, several clinically important antimicrobials including fluoroquinolones, cephems, macrolides, and several biocides including chlorhexidine (CHX). Expression of …
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Traitement neuromorphique de la parole de bout en bout et parallélisable pour les applications à faible consommation d'énergie
… et les réseaux de neurones à décharges (RND), inspirés du fonctionnement biologique, émergent comme une alternative prometteuse en offrant une meilleure efficacité énergétique. Malgré ce potentiel, les RND font face à des défis persistants liés à l'entrainement, à l’architecture des …
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Analysis of resistance nodulation division efflux pumps in Acinetobacter baumannii
… expressed resistance nodulation division (RND) efflux pump was adeFGH. A collection of A. baumannii isolates from the environment showed decreased susceptibility to at least three antibiotics and expression of three RND efflux pumps (adeFGH, adeABC, adeIJK). From the clinical collection two …
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Single copy gene expression system as a tool for the purification of membrane proteins from Pseudomonas aeruginosa
… by action of the Resistance Nodulation Division (RND) family of efflux pumps. These pumps are composed of three proteins; an inner membrane RND pump, a periplasmic membrane fusion adaptor protein, and an outer membrane protein. The mechanism by which the three proteins interact to form a …
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Reciprocal Negative Disclosures: An Application of Expectancy Violations Theory
… indicated that positive valence violations of RND regarding mental health were not perceived as more unexpected than positive valence violations of workload RND; relational quality did not correlate with expectedness of negative valence violations; negative valence mental health violations …
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Genetic and Biochemical Characterization of the Mechanisms Concerning the TraR/AAI/TraM Mediated Quorum Sensing That Regulates Ti Plasmid Conjugation
… transcription. I also found that a functional rnd gene is required for proper induction of tra genes on the Ti plasmid. Further studies suggest that mutations in rnd affect expression of traR at the post-transcriptional level. Finally, I have cloned and characterized a tetracycline resistance …
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The role of Rnd3 in kidney morphogenesis and function
… of ADPKD phenotypes, a novel mouse model Rnd3tm1b(EUCOMM)Hmgu was generated. Rnd3 is an atypical member of the Rnd subgroup of the Rho family of GTPases and has a role in actin cytoskeleton reorganisation, cell cycle progression, and cell migration. The characterisation of the kidney …
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Structural and Mechanistic Studies of Multidrug Resistance Efflux Pumps in Multiple Families
… the Resistance-Nodulation-Cell Division (RND) superfamily contains one of the most well-studied drug efflux complexes: AcrAB-TolC. Though numerous structures exist for this multi-protein assembly, none have been obtained without use of detergents that displace natural lipids which may be …
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Genetic mechanisms contributing to antimicrobial resistance: gene repression in Mycobacterium, gene transfer in Salmonella, and phage sensitivity in Escherichia
… the downstream Resistance Nodulation Division (RND) efflux pump mmpSL. To test this, we assembled multigene constructs on a plasmid with the modular cloning (MoClo) toolkit, which allowed us to control the expression of mmpT5 with the lacZ promoter and monitor mmpSL promoter activity with a …
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The Role of Multidrug Efflux Pumps in the Stress Response of Pseudomonas aeruginosa to Organic Contamination
… that the resistance nodulation-cell division (RND) efflux pump, MexAB-OprM, in particular is responsible for the PCP-induced increase in antibiotic resistance. Both whole cell physiological indicators and whole genome analysis were used to examine the stress response of <i>P. aeruginosa</i> to …
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Molecular Mechanisms of Antibacterial Resistance Among Pseudomonas aeruginosa: Multi-Drug Efflux Pumps and Their Interactions with Other Resistance Mechanisms
… classes of antibiotics. The overproduction of RND pumps can lead to high-level, multi-drug resistant phenotypes. The goal of this research was to understand how the expression of these pumps are governed in wild-type susceptible and drug resistant mutants and how these pumps interact with other …
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Dynamic catch-effort models for the southern African hake populations
… . Afric:·a · a'r-e reviewed b'r-iefly ;:rnd the obJectives of fishery tttar1age11'1e·nt defined. This is followed by a presentation of the data l..tsed ir1 subseql..te't"1t calc::-l..tlations together with details of the sc:ti..lrces fr'otrJ whic:·h they were obtai't"1ed. 1'he basis for …
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Psychological and Family Variables Associated with the Treatment of Pediatric Idiopathic Pain
<p>The present study examined variability in treatment outcomes of children with idiopathic chronic pain. Specifically, the biopsychosocial model was used as a framework to consider the way that symptoms of depression and anxiety as well as parent response to pain contributed to the change in a …
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Investigation of Crashes Involving Vulnerable Roadway Users Utilizing Geographical Information Systems-Driven Spatio-Temporal Statistical Techniques
… Distance (ED) and Roadway Network Distance (RND)-based Kernel Density Estimation (KDE). According to the GIS maps developed in this dissertation, there are differences in spatial patterns between vulnerable roadway users involved in crashes. In conclusion, this dissertation proposes a number …