Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"RNAsequencing"”.
-
Pareto Task Inference Analysis of Single-Cell RNASequencing of Human Placenta Reveals Biological Insightsinto Adverse Pregnancy Outcomes
Adverse pregnancy outcomes (APOs), such as preeclampsia, fetal growth restriction, and preterm birth, occur in 10-15% of pregnancies. There is limited knowledge of how the cellular states in the placenta and decidua tissues are altered in women with particular APOs or may contribute to APOs. …
-
RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
… cells to maintain therapy-resistance. Using RNAsequencing—an innovative approach for quantifying gene expression changes—this dissertation sought to elucidate chemoresistance-associated molecular pathways as a catalyst to develop new therapeutic targets. Results revealed a differential …
-
IDENTIFICATION OF KEY MOLECULES IN PLACODE-DERIVED NEURONS THAT COORDINATE CHICK TRIGEMINAL GANGLIOGENESIS
… molecules involved in this process, we performed RNAsequencing on the forming chick trigeminal ganglion when only placode cells contribute neurons and identified Neurogenin2 (Neurog2), Neuronal Differentiation 1 (NeuroD1), and Elongator acetyltransferase complex subunit 1 (Elp1) for further study. …
-
Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration
… human brain tissue samples. Using single-nucleus RNAsequencing (snRNA-seq), we profile cerebrovascular nuclei across 11 subtypes, including endothelial cells, mural cells, and perivascular fibroblasts. We uncover human-specific expression patterns along the arteriovenous axis and determine …
-
Transcriptional regulators in stem cell biology
… stem cell (MeSC) maintenance and function. RNAsequencing of MeSCs established that BMI1 loss leads to derepression of Cdkn2a and developmental transcription factor genes. Additionally, we observe downregulation of glutathione S-transferases, suggesting that reactive oxygen species (ROS) may …
-
Molecular Mechanisms and Antigen Receptor Requirements for Lymphocyte Adaptation to Intestinal Tissues
… by integrating mouse genetics with single-cell RNAsequencing analyses. Transcriptionally, CD4+ T cells from mLN, LP and IE segregate based on the intestinal layer they occupy; trajectory analysis suggests a stepwise loss of CD4-programming and acquisition of an intraepithelial profile as CD4+ T …
-
Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
… GLP-1 release from L-cells, we initially used RNAsequencing techniques to generate transcriptomic datasets of EECs. These datasets facilitated the investigation of EEC expression of “mechanosensors”, which could convert mechanical stimuli, such as pressure, to hormone release. We described …
-
Intra-Regional Differences in Cerebellar Vulnerability of Spinocerebellar Ataxia Type 1 Mice
Increasing evidence demonstrates distinct regional differences across the cerebellum, yet whether these differences contribute to selective vulnerability in cerebellar disease remains an open question. Spinocerebellar Ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease caused …