Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 867 for “"RNAs"”.
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Detektion funktioneller RNAs in Genomsequenzen
… sowohl die Vorhersage neuer, bisher unbekannter fRNAs, als auch die Vorhersage der Mitglieder bereits bekannter Familien. Hierbei ist kein Expertenwissen zu den einzelnen verwendeten Werkzeugen erforderlich.Die fRNA-Vorhersage basiert auf zwei Säulen. Die erste Säule ist ein komparativer Ansatz, …
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Roles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans
There are three distinct classes of small RNAs found in animals: microRNAs (miRNAs), piwi interacting RNAs (piRNAs), and small interfering RNAs (siRNAs). miRNAs are required throughout development, whereas piRNAs and siRNAs are best known for their roles in germline development and genome defense …
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Genome regulation by long noncoding RNAs
… also produce thousands of long non-coding RNAs (lncRNAs), some of which are now known to play essential roles in diverse biological processes including cellular differentiation and human disease. Recent studies show that many lncRNAs localize to the nucleus and interact with chromatin …
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Modulation of Alphaviruses by Small RNAs
… intermediates (RIs) into small interfering RNAs (siRNAs; ~21-24 nucleotides). One strand of the siRNA duplex guides the targeting and destruction of complementary viral RNAs when loaded and retained in a multi-protein complex called the RNA-induced silencing complex. Here, we show that …
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Biogenesis of Y RNA–derived small RNAs
Small non-coding RNAs (sRNAs) constitute a significant portion of the transcriptome in eukaryotes. Many of these sRNAs regulate gene expression. Next-generation sequencing (NGS) has revealed a plethora of previously uncharacterised sRNAs with potential biological function, a number of which …
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Differential expression of small RNAs in soybean
Small RNAs are non-protein coding RNAs that regulate gene expression in plants primarily by cleaving mRNA. Two major classes of small non-coding RNAs are microRNAs (miRNAs) and short interfering RNAs (siRNAs) of 21-24 nucleotides. I selected some small RNAs that show tissue specificity based on …
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Functional large non-coding RNAs in mammals
… vast and diverse functions. These functional RNAs include the ribosomal, transfer, and splicing-associated RNAs along with a cast of tiny RNAs, including microRNAs and other families. In addition to these classic examples, there were a handful of known functional large ncRNAs that play …
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Translation of Partially Decayed Messenger RNAs in Yeast
… that these viral Xrn1-resistant structures (xrRNAs) can be used to protect specific homologously-expressed messenger RNAs from 5’→3’ degradation. We investigated the effects of addition of xrRNAs, artificially-installed into the intergenic region of bicistronic mRNA reporters, in the observed …
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The role of small RNAs in C4 photosynthesis
… of the C4 cycle may be targeted by microRNAs (miRNAs). To explore this, a library of sRNA sequences from mature leaf tissue of the model C4 species Cleome gynandra L. was generated and then searched against a list of expressed sequence tag sequences for candidate genes of the C4 cycle. To …
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Small RNAs in Tomato: from defence to development
… As part of the silencing machinery, micro (mi)RNAs orchestrate silencing of their targets, either directly or through cascades of secondary small interfering (si)RNAs. To investigate the role of RNA silencing in plant immunity, I chose to focus on the miR482/2118 family, because of its …
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Translational regulation by short RNAs in mammalian cells
… RNA itself, in the form of [approx.]21nt short RNAs, was discovered to have major generalized roles in the regulation of mRNAs which are typically 100 times larger in size. These short RNAs, siRNAs and microRNAs, exert their influence on gene expression in mammals by RNA interference (RNAi) and …
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Aminoacylation kinetics and specificity for viral genomic RNAs
The esterification of amino acids to the tRNA-like structures of viral genomic RNA was studied as catalyzed by amino acyl tRNA synthetases from E. coli, yeast, bean and rat. Peanut stunt virus RNA was esterified with tyrosine in the presence of bean tyrosyl-tRNA synthetase to a maximum of 22 mole …
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Novel Algorithms for Structural Alignment of Non-coding RNAs
Non-coding RNAs are biologically important molecules, with a variety of catalytic and regulatory activities mediated by their secondary and tertiary structures. Base-pairing interactions, particularly at the secondary structure level, are an important tool for identifying and studying these …
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
… found that active enhancers often generate ncRNAs that are termed enhancer RNAs (eRNAs). Emerging studies illustrated that at least some eRNAs can recruit transcriptional regulatory proteins and promote enhancer-promoter interaction to enhance the transcription of the target genes. In cancers, …
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A TALE OF TWO METHYLATION MODIFICATIONS IN ARCHAEAL RNAs
<p>In all the three domains of life, most RNAs undergo post transcriptional modifications both on the bases as well as the ribose sugars of the individual ribonucleotides. 2'-O-methylation of ribose sugars and isomerization of Uridines to Pseudouridines are two most predominant modifications in …
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Genome wide search for pseudo knotted non-coding RNAs
Non-coding RNAs (ncRNAs) are the functional RNA molecules that are involved in many biological processes including gene regulation, chromosome replication and RNA modification. Searching genomes using computational methods has become an important asset for prediction and annotation of ncRNAs. To …
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Comparative transcriptomics of long intergenic noncoding RNAs in Drosophila
… the amino acid code, long intergenic noncoding RNAs (lincRNAs) can be expected to evolve along different trajectories than protein-coding genes. Most studies of lincRNA evolution analyze evolution only at the sequence level without ascertaining whether the lincRNA is expressed. Over 2,000 …
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M6A Reshapes the Folding and Recognition Landscape of RNAs
<p>Ribonucleic acid (RNA) is a versatile and dynamic biomolecule that serves as an indispensable component in the central dogma of molecular biology. The realization that RNA plays a wide variety of roles in gene expression and regulation has been accompanied by the discovery that virtually all …
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