Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"RNAinterference"”.
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Characterization of Mechanisms That Mediate Cancer Metastatic Colonization
… therapeutic strategies. An in vivo large-scale RNAinterference screen was performed to identify genes required for liver colonization. Liver and red blood cell pyruvate kinase (PKLR) was identified as a driver of liver metastasis in experimental models. In patients, PKLR was found to be …
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Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
Cancer has become more and more prevalent over the last few years, reaching its highest levels per capita in the Western world in 2008. Mutations that produce dominant gain of function oncogenes and loss of function tumor suppressor genes have been discovered due to their alteration in human and …