Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"RNA-protein complexes"”.
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Single molecule pull-down of viral RNA-protein complexes
Protein and RNA molecules interact with multiple protein partners to perform essential cellular processes such as post-transcriptional regulation of mRNA. Recently, a single molecule pull-down (SiMPull) assay was developed to isolate and study single protein complexes directly from cell lysates. …
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RNA recognition: controlling RNA-protein complexes with small molecules
… I. Investigation of Small Molecule Binding to an RNA Hairpin Loop Containing a Dangling End PART II. Unraveling the Interaction of Pathogenic RNAs with the MBNL1 Protein and Complex Inhibition by Small Molecules PART I. RNA plays important and versatile roles in gene expression by both carrying …
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Simulation and visualization of dynamics in RNA-protein complexes in translation
… information and synthesizing the corresponding proteins, is universal and found throughout the three domains of life. The flow of information in translation involves a series of distinct but highly conserved RNA·protein complexes with the ribosome being the largest ribonucleoprotein complex in …
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Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor
… of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease and the biological roles of the recognized antigens. These antibodies are some of the many …
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A study of chromatin dynamics during transcription by fluorescence light microscopy
The genes of eukaryotes exist as DNA-RNA-protein complexes known as chromatin. The structure of chromatin fluctuates to allow controlled access to genetic information while maintaining its important packaging function. Recent improvements in optics, image acquisition electronics, and live imaging …
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NMR Studies of the RNA Binding Domain of U1A protein and its Complexes with RNA
Eukaryotic splicing is catalysed by five RNA protein complexes called snRNP's. U1A is one protein component of the U1 snRNP particle. The role of U1A in splicing is unclear, but it does bind a hairpin loop from U1 RNA. U1A also binds two internal bulges found in the 3' untranslated region of the …
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Functional large non-coding RNAs in mammals
It is now clear that RNA is more than a messenger and performs vast and diverse functions. These functional RNAs include the ribosomal, transfer, and splicing-associated RNAs along with a cast of tiny RNAs, including microRNAs and other families. In addition to these classic examples, there were a …
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GUIDE RNA-DEPENDENT AND INDEPENDENT tRNA MODIFICATIONS IN ARCHAEA
Stable RNAs undergo a wide variety of post-transcriptional modifications, that add to the functional repertoire of these molecules. Some of these modifications are catalyzed by stand-alone protein enzymes, while some others are catalyzed by RNA-protein complexes. tRNAs from all domains of life …
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Investigating the regulation of processing bodies in Drosophila melanogaster oocytes
… of biomolecular condensates is ribonucleoprotein (RNP) granules. These RNA-protein complexes play critical roles in mRNA localisation, translation, and degradation. Within this category, processing bodies (P bodies) are evolutionarily conserved RNP granules found in yeast to humans. In …
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Development of Oligonucleotide-directed proximity-interactome MAPping (O-MAP), for characterizing RNA-protein interactions and higher order subnuclear architecture in situ
RNA-protein interactions underscore a broad array of regulatory mechanisms throughout biology, and dysregulation of these interactions contributes to a broad range of human pathologies such as neurodegenerative disorders and many cancers. Recent studies have discovered thousands of RNA-binding …
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Conformation of the U12-U6atac snRNA Complex of the Minor Spliceosome and Binding by NTC-related Protein RBM22
<p>Splicing of precursor messenger (pre-m)RNA is a critical process in eukaryotes in which the non-coding regions, called introns, are removed and coding regions, or exons, are ligated to form a mature mRNA. This process is catalyzed by the spliceosome, a multi-mega Dalton ribonucleoprotein complex …