Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RNA-RNA Interactions"”.
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Bioinformatic methods for analyses of epigenome and RNA interactome
… is far from complete, particularly on non-coding RNAs and regulatory sequences. Epigenomic modifications and variations were considered to contribute to the diversity of functions found across different cell types, play key roles in the establishment and maintenance of cellular identity during …
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The evolution, modifications and interactions of proteins and RNAs
Proteins and RNAs are two of the most versatile macromolecules that carry out almost all functions within living organisms. In this thesis I have explored evolutionary and regulatory aspects of proteins and RNAs by studying their structures, modifications and interactions. In the first chapter of …
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M6A Reshapes the Folding and Recognition Landscape of RNAs
<p>Ribonucleic acid (RNA) is a versatile and dynamic biomolecule that serves as an indispensable component in the central dogma of molecular biology. The realization that RNA plays a wide variety of roles in gene expression and regulation has been accompanied by the discovery that virtually all …
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Study Of Protein-Rna Interactions Using Fluorescence Resonance Energy Transfer (fret) And Single-Molecule Fret
<p>In the cell, RNA and protein, interact to form ribonucleoprotein complexes (RNPs) that have vital structural, catalytic and regulatory roles. Despite their functional importance, the mechanistic details and dynamics of RNPs are poorly understood. Single-molecule Fluorescence Resonance Energy …
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Mechanistic analysis of the Zika virus translation-replication switch
The genomes of positive-sense RNA viruses are required for both translation and replication during infection. These two processes are antagonistic in nature, each requiring the RNA template in opposite directions. Thus, the balance between these processes during infection must be tightly regulated. …
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Investigating Hfq-Mrna Interactions In Bacteria
<p>Regulatory RNAs (sRNAs) are essential for bacteria to thrive in diverse environments and they also play a key role in virulence [11]. Trans-sRNAs affect the stability and/or translation of their target mRNAs through complementary base-pairing. The base-pairing interaction is not perfect and …
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Studying the riboregulatory role of Hfq in Klebsiella pneumoniae using CLASH (crosslinking, ligation and sequencing of hybrids)
… the gene expression before translating the mRNAs into proteins. PTR mechanisms involve rewiring the gene expression using small non-coding RNAs (sRNA) and RNA binding proteins (RBPs). In this study, I investigated Hfq, an RBP in a Gram-negative nosocomial pathogen Klebsiella pneumoniae (Kp), …
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Single molecule study of weak and transient biological interactions
… resolution. Here we present unique interactions between proteins and nucleic acids which were previously unattainable with conventional single molecule techniques.
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snoDB: An interconnected online database of human snoRNA
RNA is more than just a transitory molecule between DNA and proteins. Beyond the scope of protein-coding RNAs lies a vast underexplored landscape of non-coding RNAs (ncRNA). These RNAs have been slowly uncovered since the 1960s but it took until the turn of the century, and the advent of …