Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 183 for “"RNA-Binding Proteins"”.
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RNA-binding proteins in yeast mitochondria
… 1 (Mdh1p) both of which have been identified as RNA-binding proteins without known RNA recognition motifs. Besides analysing their effects on mitochondrial translation and their organisation in protein complexes the work focused on the characterisation of the RNA-binding properties of recombinant …
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Investigation of m6A-regulated RNA-binding proteins
… the most ubiquitous modifications of eukaryotic RNAs. The modifi- cation functions to control the normal processing, export, splicing, and metabolism of cellular RNAs. All of these processes are mediated by a group of m6A RNA-binding proteins known as ‘readers’ that bind modified RNA - directly …
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RNA binding proteins in neurotoxic protein clearance
… of damaged cellular components, misfolded proteins, and aggregates leads to the accumulation of neurotoxic proteins, and an increase in cellular stressors such as reactive oxygen species – eventually causing neuronal cell death. In the case of PD, neuronal inclusions are composed primarily …
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Understanding regulation of mRNA by RNA binding proteins
Posttranscriptional regulation of mRNA by RNA-binding proteins plays key roles in regulating the transcriptome over the course of development, between tissues and in disease states. The specific interactions between mRNA and protein are controlled by the proteins' inherent affinities for different …
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Biochemical and functional characterization of human RNA binding proteins
RNA not only shuttles information between DNA and proteins but also carries out many other essential cellular functions. Nearly all steps of an RNA's life cycle are controlled by approximately one thousand RNA binding proteins (RBPs) that direct RNA splicing, cleavage and polyadenylation, …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… The-HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 expression is induced in diseased, but not normal arteries. SiRNA knock down of FXR1 increases abundance and stability of inflammatory mRNAs, while overexpression …
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Single molecule pull down of double strand RNA binding proteins
RNA molecules are transcribed as single stranded naturally, but with most of them forming in to structures composed of duplex regions, loop, bulge or mismatches. RNAs with double stranded regions, or known as double-strand RNAs (dsRNAs). The class of proteins responsible for processing dsRNAs is …
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Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… and encodes thousands of long noncoding RNAs (lncRNAs). Defining the mechanism of action of lncRNAs has been a critical challenge and priority for understanding their biological functions. An important example of this is the lncRNA NORAD, which is a highly conserved lncRNA that is …
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Computational analysis of cooperation and competition mechanisms between RNA-binding proteins
… regulatory trans-elements forming this network, RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of gene expression (PTR). Understanding RBPs behavior is therefore crucial given their participation in all stages of the mRNA life cycle. Although an increasing amount of …
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RNA binding proteins and snoRNAs change the ribosome dynamics in translation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Functional and computational analysis of RNA-binding proteins and their roles in cancer
This work is concerned with mRNA processing in mammalian cells and proceeds in two parts. In the first part, I introduce a computational framework for inferring the abundances of mRNA isoforms using high-throughput RNA sequencing data. This framework was applied to study the targets of the …
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Molecular and functional characterisation of circadian clock regulated RNA-binding proteins from Arabidopsis thaliana
The clock-regulated small RNA-binding protein AtGRP7 (Arabidopsis thaliana glycinerich RNA-binding protein) influences its own circadian oscillations by negative autoregulation at the post-transcriptional level, presumably by binding to its own transcript. The present work analyses the RNA-binding …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… of gene expression is mediated in part by RNA binding proteins (RBPs). The ZFP36 family of RBPs are key regulators of gene expression in the immune system. The founding member ZFP36 is a well-known regulator of cytokine mRNA stability. Paralogs ZFP36L1 and ZFP36L2 act redundantly during …
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RNA-binding Proteins and RNA-DNA Hybrids Regulate Repetitive DNA Stability in Health and Disease
… safeguard the integrity of repetitive loci. The RNA-binding protein Ataxin-2 (Pbp1 in yeast) regulates the stability of rDNA and yeast Ty1 retrotransposons. Interestingly, the human protein (ATXN2) undergoes trinucleotide repeat expansion in the neurodegenerative diseases spinocerebellar ataxia …
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Characterization of the Roles of Intrinsically Disordered Regions from RNA-Binding Proteins in Phase Separation
… are membrane-less organelles that enrich RNA and RNA-binding proteins containing intrinsically disordered regions (IDRs). I demonstrate that IDRs, coupled with RNA binding domain and RNA, can phase separate in vitro, producing dynamic liquid droplets. Over time, these droplets mature into …
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Multilayered regulation of translation: roles of rRNA modifications, alternative initiation factors, and RNA-binding proteins
… in gene expression, where the ribosome decodes mRNA to synthesize proteins. This dissertation explores distinct regulatory layers that influence translation initiation and ribosome function, focusing on alternative initiation factors, ribosomal RNA modifications, and RNA-binding proteins. First, …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… and relapse. Recent studies indicate that RNA-binding proteins (RBPs) appear to play a particularly important role in cancer, and may contribute to chemoresistance, but the field is still at an early stage and nothing has yet progressed towards translational utility. This is at least …
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Role of the Hu family of RNA-binding proteins in regulating acetylcholinesterase expression in excitatory cells
… even though several studies have implicated mRNA stability as a means of controlling expression. We have, therefore, undertaken studies examining the role of post-transcriptional mechanisms in regulating AChE mRNA levels during neuronal differentiation, myogenic differentiation and in vivo …
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