Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"RNA viruses"”.
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Novel acyclic nucleotide phosphonates against RNA viruses
… of the only drugs available for the treatment of RNA-viral infections which mainly affect the developing world. The large and unmet need for anti-RNA viral treatments has prompted this study into the design and synthesis of a range of ANPs, which includes a series of ribavirin-based ANP …
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Algorithm development for RNA structure prediction in RNA viruses
RNA structures play many different roles in the life cycles of RNA viruses, including in directing translational control, genome replication, subgenomic RNA synthesis, and encapsidation. However, predicting these structures can be challenging, especially when it comes to pseudoknots, long-range …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… critical facet of the innate immune response to viruses. Since virtually every subcellular compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral threats. In this thesis, we explored the …
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The development and use of cutting edge next generation sequencing methodologies to study RNA viruses
… being published often, our ability to sequence viruses and host transcriptomes (in response to viral infection) has expanded – driving virology forward. Here we show the development and use of novel methodologies to study RNA viruses from their impact on the host, to variations in viral genomes, …
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Interactions Between the Odorous House Ant (Tapinoma sessile) and RNA Viruses: a Multi-Faceted Approach
… course of my thesis, I characterized four novel viruses in T. sessile using metatranscriptomic analysis, investigated their infectivity, and explored how colony social organization influences viral infection patterns. Inoculation experiments confirmed active infection in T. sessile colonies, …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… areas of research that warrant further study. RNA viruses have since been at the forefront for pandemic and prevention preparedness due to their increased potential to cause future outbreaks. SARS-CoV-2 and Venezuelan equine encephalitis virus (VEEV) are both zoonotic positive-sense …
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Persistent RNA Viruses of Common Bean (Phaseolus vulgaris): Distribution and Interaction with the Host and Acute Plant Viruses
… can be infected with acute and persistent plant viruses. A modified dsRNA extraction method was developed and used in this study. The method was fast, economic, versatile, and required relatively small amounts of desiccated plant tissue. The method was successfully used to extract dsRNAs from …
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Identification and mode of action studies of new potent inhibitors of the RNA viruses HCV, BVDV and RSV
… of worldwide emerging infections are caused by RNA viruses. For this reason, research in the antiviral chemotherapy field is directed toward the development of compounds that target various steps of the virus life cycle. In this work the antiviral activity of 5-Acetyl-2- Arylbenzimidazoles and …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… signaling pathways in response to viral dsRNA leading to the activation of interferon regulatory transcription factors IRF3, IRF7 and NF-κB. These transcription factors mediate inflammatory process to clear virus infection. Viruses can evade host antiviral defenses by using several …
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The spread and evolution of RNA viruses among honey bees and the wider insect community with particular emphasis on deformed wing virus (DWV)
… in the Northern hemisphere. The spread of RNA viruses, most notably Deformed wing virus (DWV) in association with its vector, the ectoparasitic Varroa destructor mite are now widely accepted as a major factor in these colony losses. This has had a devastating effect on beekeepers and …
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The Interferon Stimulated Gene Product Lymphocyte Antigen 6 Complex, Locus E Promotes Entry of a Subset of Diverse RNA Viruses and Inhibits Infection by Coronaviruses
… in the screen to enhance the infection of viruses from Flaviviridae, Orthomyxoviridae, Retroviridae, and Alphaviridae viral families. In my studies, I confirmed that LY6E promotes viral infection of viruses from the same families, as demonstrated by both ectopic overexpression and …
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Factors That Influence Mammalian Enteric Virus Infection
RNA viruses are a common cause of emerging diseases due to their vast genetic diversity. This diversity is largely attributed to mutations generated by the error-prone viral RNA-dependent RNA polymerase during replication. Despite the ability to acquire mutations beneficial to the virus, most …
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The evolution and genetics of virus resistance in Drosophila
… to study the genetic basis of resistance against RNA viruses. To understand the genetic basis of infection between different viral and Drosophila genotypes, I investigated two classic models, gene-for-gene and matching-allele models. These models consider that the outcome of the infection depends …
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Assessing and understanding the generation and function of RNA decay intermediates in non-insect borne flaviviruses
… correctly to stimuli or to maintain homeostasis. RNA viruses must act to preferentially drive production of their own messenger RNAs (mRNAs) and proteins in order to successfully replicate and ensure continued infection. Due to the necessity for RNA viruses to remain in the cytoplasm, regulatory …
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Protein Folding, Host Cell Proteostasis, and Viral Evolution
Pandemics and epidemics caused by pathological RNA viruses, such as the 1918 influenza pandemic, the global AIDS epidemic, and the recent coronavirus pandemic, impose a severe burden on global health and the economy. A major challenge associated with developing effective antiviral strategies is the …
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Characterization of an Amphipathic Alpha-Helix in the Membrane Targeting and Viral Genome Replication of Brome Mosaic Virus
Positive-strand RNA viruses associate with specific organelle membranes of host cells to establish viral replication complexes. The replication protein 1a of brome mosaic virus associates strongly with the nuclear endoplasmic reticulum (ER) membranes, invaginates membranes into the lumen, and …
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LUBAC is required for the RIG-I mediated antiviral response
RNA viruses are responsible for many of the most recent threats to human health by emerging infectious diseases, including epidemics caused by Influenza, Zika, Dengue and novel Coronaviruses. The body’s first line of defence against viruses is the innate immune system. Pattern recognition receptors …
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Identification and characterization of host genes involved in regulating replication of brome mosaic virus
… belongs to a viral class called positive-strand RNA [(+)RNA] viruses. This is the largest class of viruses and includes numerous important pathogens. BMV infects monocotyledonous plants and its replication can be recapitulated in the baker's yeast (Saccharomyces cerevisiae) under laboratory …
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Viral Inhibition of Mammalian Cell DNA Synthesis
… for in vivo regulated DNA replication. Animal viruses can be used as tools to study cellular DNA replication. Certain RNA viruses which multiply in the cytoplasm of host cells inhibit cellular DNA synthesis. The work described in this thesis represents an effort to locate the step in cellular …
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