Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"RNA virus"”.
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Mechanisms of Emerging RNA Virus Adaptation to Hosts
Emerging RNA viruses cause acute and chronic diseases that threaten the livelihoods of people in regions where the virus is endemic. As factors such as climate change and increased globalization, travel, and trade alter the co-occurrence of humans and reservoirs or vectors, opportunities for viral …
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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing
<p>Two RNA virus families that pose a threat to human and animal health are Hantaviridae and Coronaviridae. These RNA viruses which originate in wildlife continue and will continue to cause disease, and hence, it is critical that scientific research define the mechanisms as to how these viruses …
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
Catalytic antibodies against viruses have been constantly developed in preventive or therapeutic fields to target viral antigens effectively. 3D8 is an anti-DNA catalytic antibody that binds to DNA and RNA then degrades them without sequence specificity as well known as Abzymes. Previously it was …
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The role of RNA structures in the evolution of respiratory RNA virus genomes.
RNA secondary structures in RNA viral genomes play important roles in a range of functions, including packaging, protection from cellular nucleases, and regulating viral replication. Furthermore, RNA structures have been shown to be immunostimulatory. In the case of Influenza A virus (IAV), during …
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A RNA Virus Reference Database (RVRD) to Enhance Virus Detection in Metagenomic Data
… virome composition and discovering novel virus species, there is a pressing demand for comprehensive and up-to-date reference databases to enhance the downstream bioinformatics analysis. In this study, a RNA virus reference database (RVRD) was developed by manual and computational curation …
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Identification of Leishmania tropica and Leishmania aethiopica by DNA sequencing and the detection of Leishmania RNA Virus
… are indeed different species. The Leishmania RNA Virus is a double stranded RNA virus which infects Leishmania and is thought to increase the pathology of the disease and exacerbating mucosal developments. The methods used in this study were polymerase chain reaction and sequencing for the …
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DEFINING THE ROLE OF LIPID DROPLET SCAFFOLDING PROTEINS IN HEPATIC STEATOSIS INDUCED BY HEPATITIS C VIRUS CORE PROTEIN
Hepatitis C Virus (HCV) is an enveloped RNA virus responsible for 170
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Protein-Protein and Protein-Rna Interactions in the in Vitro Assembly of the R17 Bacteriophage
… R17 bacteriophage is a positive single stranded RNA virus that specifically infects male strains of E. coli. The role of RNA protein interactions in the in vitro assembly of the virus is examined in order to determine both what features of the RNA are important for its selective packaging by R17 …
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Factors That Influence Mammalian Enteric Virus Infection
RNA viruses are a common cause of emerging diseases due to their vast genetic diversity. This diversity is largely attributed to mutations generated by the error-prone viral RNA-dependent RNA polymerase during replication. Despite the ability to acquire mutations beneficial to the virus, most …
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Characterization of a Low-Fidelity Live-Attenuated Vaccine for Venezuelan Equine Encephalitis Virus
During RNA virus replication, there is the potential to incorporate mutations that affect virulence or pathogenesis. For live-attenuated vaccines, this has implications for stability, as replication may result in mutations that either restore the wild-type phenotype via reversion or compensate for …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogenics affecting swine industry worldwide. PRRSV is a single-stranded and positive sense RNA virus that belongs to the family of the Arteriviridae (genus Arterivirus). PRRSV has a restricted …
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Characterization of Attachment and Receptor Isolation of Infectious Pancreatic Necrosis Virus to Chse-214 Cells
Infectious Pancreatic Necrosis Virus (IPNV) is a bisegmented, double stranded RNA virus with a protein capsid and no envelope and is classified in the group, Birnaviridae. Although much is known about viral genes and proteins, the initial stages of attachment to susceptible cells are not known and …
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Techniques of RNA Isolation and Characterization in Infectious Pancreatic Necrosis Virus-Infected Chinook Salmon Embryo Cells
Infectious pancreatic necrosis virus (IPNV) causes the most lethal disease in young salmonid fishes with mortality rates of equal or higher than ninety-five percent. The survival of the adult fish has been the main cause of this virus's proliferation around the world, making it the most …
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Mixed Strain Identification of Porcine Reproductive and Respiratory Syndrome Virus in Multiplexed Samples using Nanopore Sequencing
… Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) has been a major contributor to morbidity and mortality in the commercial swine industry across the globe. This highly mutagenic RNA virus causes significant economic losses wherever it is prevalent, leading to $664 million in annual …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
Many individuals infected with hepatitis C virus (HCV) fail to respond to therapy, resulting in the development of chronic infection and increased risk for fibrosis, cirrhosis, and hepatocellular carcinoma. The current standard of care consists of pegylated interferon and ribavirin (RBV), a …
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Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway
<p>After RNA virus infection, the innate immunity utilizes RIG-I family of receptors in the cytoplasm to initiate the production of type-I IFNs and proinflammatory cytokines by mitochondrial protein MAVS, which forms a prion-like structure to recruit TBK1and IKK complex to activate IRF3 and NF-κB, …
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Quantitative analysis of individual flue-cured tobacco seed tissues reveals Tobacco mosaic virus infection in embryos
Tobacco mosaic virus (TMV) is an extensively studied RNA virus that reduces quality and yield in commercially grown tobacco (Nicotiana tabacum L.). The virus is transmitted mechanically, although infections have been associated with contaminated seeds with the seed coat being the source of virus. …
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Prenylation in cell-intrinsic innate immunity to positive-strand RNA viruses
… critical facet of the innate immune response to viruses. Since virtually every subcellular compartment can be utilized by viruses for replication, antiviral factors must also be positioned in these compartments to effectively interact with various viral threats. In this thesis, we explored the …
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Search for etiology of porcine reproductive and neurologic syndrome: identification and characterization of a novel swine pestivirus
… A previously unrecognized small enveloped RNA virus of approximately 50 nm in size was repeatedly isolated from field cases of PRNS and tentatively named "Virus X". The disease and/or lesions of PRNS were reproduced in pregnant sows and young caesarian-derived-colostrum-deprived (CDCD) pigs …
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