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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RNA stem loop"”.
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EXPANDING THE TOOLKIT: STRUCTURE, DYNAMICS, AND DRUG INTERACTIONS OF THE “PRIMING LOOP” FROM HEPATITIS B VIRUS PRE-GENOMIC RNA BY SOLUTION NMR SPECTROSCOPY
RNAs are dynamic macromolecules that function as essential components of biological pathways that result in human disease, making them attractive therapeutic targets. Yet, RNA structural biology lags significantly behind that of proteins, limiting mechanistic understanding of RNA chemical biology. …
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Stability of Nucleic Acid Secondary Structures and Their Contribution to Gene Expression
… the first twenty-five bases of the bop gene mRNA can form a secondary structural element (a "stem-loop"). Using biophysical methods, the goal was to determine if the stem-loop structure exists in solution conditions that mimic the in vivo biological environment (42°C and 4M KCl) (2-4). The …
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Investigating the Pyrr-Pyr mRNA Interaction Through Site-Directed Mutagenesis of the PyrR Protein
… subtilis is regulated by a feedback inhibition loop involving the product of the first gene of the operon, PyrR, and the downstream products of the pathway, uridine nucleotides. Regulation occurs through a transcriptional attenuation mechanism in which PyrR binds in the presence of UMP or UTP to …
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Ochrobactrum anthropi: a soil bacterium for the study of Brucella virulence
… of the closest Brucella relatives based on DNA, rRNA, and protein analyses but it is unable to establish chronic infection and considered as opportunistic pathogen that, under certain circumstances, may produce disease in immunocompromised humans. Therefore, we established enhanced expression …