Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"RNA stability"”.
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Analysis of RNA stability in forensic specimens
Ribonucleic acid (RNA) analysis presents a unique, novel opportunity to answer a wide range of questions in forensic science. The dynamicity of the transcriptome has led to it being suggested as a novel source of diagnostic information in forensic pathology. However, RNA is exceptionally labile. …
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A novel approach for the study of sequences that control cytoplasmic RNA stability
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1987.
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New Roles in RNA Stability and Transcription for the RNA Export Protein, REF/Aly
Pre-mRNA processing consists of a series of events including capping, splicing, and polyadenylation, which occur co-transcriptionally, are interdependent, and are coupled to other steps in gene expression including transcription and RNA export. For example, in mammalian cells the TREX …
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Soybean Mosaic Virus Hc-Pro Enhances Viral Symptoms, Bean Pod Mottle Virus and Transgene RNA Stability, siRNA Accumulation, and Reduces Soybean Seed Production
… by BPMV has been linked to degradation of viral RNA by post-transcriptional gene silencing (PTGS), which is characterized by the accumulation of small interfering RNAs (siRNAs). In soybean plants infected with BPMV alone, siRNA accumulation was correlated with accumulation of BPMV genomic RNAs, …
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From cradle to grave: The influence of mRNA metabolism on plant stress responses
… necessitates complex molecular responses to external stimuli, including environmental change. As the intermediary between DNA and protein, mRNA is a crucial cog in plant gene expression, and consequently a key regulatory target. During stress, control of mRNA metabolism (and downstream protein …
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From cradle to grave: The influence of mRNA metabolism on plant stress responses
… necessitates complex molecular responses to external stimuli, including environmental change. As the intermediary between DNA and protein, mRNA is a crucial cog in plant gene expression, and consequently a key regulatory target. During stress, control of mRNA metabolism (and downstream protein …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… (NCL), involved in ribosome assembly, pre-mRNA metabolism, cytoplasmic RNA stability, and nucleo-cytoplasmic transport as well as ORF57, an mRNA transcript accumulation (MTA) viral early protein involved in posttranscriptional regulation, splicing of viral RNA transcripts, RNA stability, and …
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The analysis of a conserved RNA structure in the 3D polymerase encoding region of Human Parechovirus 1
Picornaviruses are important causes of human illness and it is necessary to understand more about how these viruses function. Human parechoviruses (HPeV) are common pathogens and studies have shown that 95% of people become infected with HPeV at a very early age, usually with symptoms such as mild …
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The Role of the Human Nuclear Poly(A) Binding Protein in RNA Decay
Control of nuclear RNA stability is an important determinant of gene expression, but the factors involved in nuclear RNA decay remain largely unknown in higher eukaryotes. Here, I describe our work showing that polyadenosine (poly(A)) tails can stimulate transcript decay in the nucleus of human …
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Acing nucleic acids and chemistry : exogenous RNA/DNA acetylation and modeling universal data formats.
N4-acetylcytidine (ac4C) is an epitranscriptomic RNA modification formed by the acetylation of the primary amine of cytosine by an N-acetyltransferase with acetyl-CoA as the acetyl donor. This highly conserved modification is involved in RNA stability and translation efficacy. The natural …
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Functional characterization of the RNA binding protein RALY
… from genome, more than 90% are subject to alternative splicing or other post-transcriptional modifications. All these events produce a high number of different proteins that form the basis for the high variety of cells. The RNAbinding proteins (RBPs) play crucial roles in this variability by …
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The Characterization of PG0228 in Porphyromonas gingivalis W83
… Studies have shown a number of small non-coding RNAs (sRNAs) have been related to bacterial virulence. Many of these sRNAs require the facilitation of the bacterial Sm-like protein, Hfq, for optimum function. Hfq is a RNA chaperone involved in RNA stability, sRNA function, and polyadenylation. …
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Stability And Recovery Of Rna In Biological Stains
In theory, RNA expression patterns, including the presence and relative abundance of particular RNA species, provide cell and tissue specific information that could be of use to forensic scientists. An mRNA based approach could allow the facile identification of the tissue components present in a …
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Exploring Protein -Rna Interactions With Site-Directed Mutagenesis and Phage Display
"The importance of RNA as a mediator of genetic information is widely appreciated. RNA molecules also participate in the regulation of various post-transcriptional activities, such as mRNA splicing, editing, RNA stability and transport. Their regulatory roles for these activities are highly …
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Exploring Protein-Rna Interactions With Site-Directed Mutagenesis and Phage Display
The importance of RNA as a mediator of genetic information is widely appreciated. RNA molecules also participate in the regulation of various post-transcriptional activities, such as mRNA splicing, editing, RNA stability and transport. Their regulatory roles for these activities are highly …
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Exploring protein-RNA interactions with site-directed mutagenesis and phage display
The importance of RNA as a mediator of genetic information is widely appreciated. RNA molecules also participate in the regulation of various post-transcriptional activities, such as mRNA splicing, editing, RNA stability and transport. Their regulatory roles for these activities are highly …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… endothelial apoptosis and its regulation at the RNA level. Methods and Results To determine the relevance of PMCA4 in PAH, the expression of PAH-associated receptors (BMPR2, ALK1, TGFβR1, Endoglin) was evaluated in lung RNA from PMCA4 wild-type and knockout mice by qPCR, showing no significant …
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Non-coding RNA genes lost in Prader-Willi Syndrome stabilize target RNAs
… There is evidence that a cluster of non-coding RNA genes in the deleted region known as the SNORD116 genes may be the most critical genes deleted in Prader-Willi Syndrome. It is unknown what the SNORD116 genes do at the molecular level, but recent evidence suggests they regulate the expression …
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Characterization of the Interactions Between Kaposi’s Sarcoma-Associated Herpesvirus ORF57 and Its RNA Partners
… levels including transcription, splicing, mRNA export, RNA stability, and translation. At least in some cases, direct interactions between ORF57 and its target RNAs are necessary for ORF57-mediated upregulation of viral gene expression. The work highlighted in this document reveals our …
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