Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"RNA sensing"”.
-
RNA sensing and programming platforms for mammalian synthetic Biology
The field of synthetic biology aims to control cellular behavior using programmable gene circuits. Generally these gene circuits sense molecular biomarkers, process these inputs and execute a desired calculated response. This is especially relevant for gene and cell therapies where integrating …
-
Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
… and combating viral infections. Double-stranded RNA (dsRNA) is a potent proinflammatory signal, and its recognition by MDA5 and its coregulatory factor, LGP2, is essential for initiating antiviral responses. This study aimed to investigate the structure and function of MDA5 and LGP2. I showed the …
-
CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… is dependent on the RIG/MAVS cytosolic RNA-sensing pathway, and is possibly triggered by increased cytosolic localisation of mitochondrial dsRNA. Using a 3D vascularised TNBC model, CHL-4 treatment increased peritumour accumulation of PBMCs compared to control treatment. Furthermore, …
-
Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
… engineered to be deficient in the viral RNA-sensing pathway, as the result of genetic ablation of the host proteins RIG-I and MDA5. This study was carried out to determine the importance of RIG-I and MDA5 in providing innate immune protection against Pichinde virus in mice, which may shed …
-
Bacteroides fragilis outer membrane vesicles are used for secretion of a discrete subset of bacterial RNAs that stimulate an immune response in colonic epithelial cells.
… response system are receptors capable of sensing foreign nucleic acids (e.g. small RNAs) that are carried as cargo in bacterial outer membrane vesicles (OMVs). The mechanisms by which human extracellular RNAs elicit immune responses have been well established, while the contribution of …
-
Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
… Analysis of host cell pathways by the use of siRNA knockdown demonstrated that cytokine secretion induced by both the Le and P/V mutants was dependent on production of dsRNA and RIG-I, an RNA sensing PRR. Overexpression experiments demonstrated that cytokine induction did not involve TLR3. …
-
Identification of viral and cellular factors that modulate heterogeneity in IFN induction during influenza infection
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01