Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"RNA replicase"”.
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it has become clear that intracellular dsRNA is more effective than extracellular dsRNA in promoting apoptosis and orchestrating adaptive immune response. To overcome the …
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[RNA polymerase ribozymes]
The RNA World is a hypothetical ancient evolutionary era during which RNA was both genome and catalyst. During that time, RNA was the only kind of enzyme yet in existence, and one of its chief duties was the replication of RNA. This scenario presupposes that among all possible RNA sequences, there …
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Purification and Properties of Bacteriophage f2 Replicase
… concerns the purification and properties of an RNA-dependent ribonucleotide-polymerizing enzyme (RNA replicase) produced during infection of E. coli with the RNA bacteriophage f2. Studies on the RNA replicase of the distantly-related bacteriophage Q3 have established the feasibility of using a …
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Ice as a medium for RNA-catalysed RNA synthesis and evolution
… self-replication and evolution. According to the RNA World hypothesis, this could have been an RNA polymerase ribozyme capable of generating copies of itself from simple nucleotide precursors. In vitro evolution experiments have provided modern examples of such ribozymes, such as the R18 RNA …
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Evolution and Engineering of RNA-based Macromolecular Machines
The “RNA World Hypothesis” posits that extant life was likely preceded by a simpler primordial biology lacking DNA and proteins, relying instead on RNA for both heredity and catalysis. An essential component of an RNA world scenario would be an RNA “replicase” – a ribozyme capable of …
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Computational Techniques Applied to RNA Structures and Bacterial Genomes
… how complexity might arise in a prebiotic RNA World in which RNA polymerization through an RNA replicase was not possible. The experimental system exposes an initial 20-mer seed RNA to 180 min of continuous cycles of synthesis and degradation. The resulting pools of RNA were characterized …