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Showing 1 to 6 of 6 for “"RNA repair"”.
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Discovery and characterization of novel RNA repair systems
RNA is one of the major macromolecules essential for all known forms of life. RNA in the cell is subject to many types of damage as DNA, and the ubiquitous RNA degradation by surveillance machinery is an important way to respond RNA damage. However, RNA repair is an alternative way for cells to …
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Probing substrate specificity of RNA repair protein Pnkp/Hen1 from Anabaena variabilis
… in vitro study of the substrate specificity of a RNA-repair protein Pnkp/Hen1 from bacteria Anabaena Variabilis. Following the previous discovery of a RNA repair protein—Pnkp/Hen1, which can repair ribotoxin cleaved tRNA in vitro and can add a methyl group at the cleaved site to prevent further …
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Biochemical and Structural Studies of RNA Modification and Repair
"""RNA Repair"" is a mechanism that rectifies purposeful breaks in tRNAs and mRNAs occurred during RNA processing and under cellular stress. To date, only two repair-like and repair pathways have been identified: yeast-type and phage-type, respectively. In our studies, we identified a bacterial RNA …
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Biochemical and structural studies of RNA damage and repair in bacteria
… endonucleases which typically target RNA molecules that are necessary for translation mainly, tRNAs and rRNAs which can result in their loss of function. In order to respond to RNA damage, some organisms have developed RNA repair systems which can heal and seal the cleaved RNA molecule …
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Biochemical and Structures Studies of tRNA Modificaton and Repair Enzymes
Plant siRNAs and miRNAs are methylated at their 3' ends at the 2' OH position by Hen1, an S-Adomet dependent methyltransferase. Hen1 homologs in animals are shown to be responsible for the methylation of piRNAs, some siRNAs as well as endogenous siRNAs. Interestingly, a subset of bacteria also has …
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Characterization of RNA damage and repair in bacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01