Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"RNA regulation"”.
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Models of dynamic RNA regulation in mammalian cells
… changes in the cellular circuits that control RNA levels in mammalian cells, focusing on the model response of immune dendritic cells to pathogens, through an integration of comprehensive computational models and innovative empirical approaches. I establish a computational framework to follow …
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RNA regulation of polysaccharide metabolism in human gut Bacteroidetes
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Genome-Wide Decoding of mRNP and miRNA Maps
… possibility that much of the complexity in the regulation of gene expression may be determined by RNA regulation controlled by RNA-binding proteins (RNABPs) and/or microRNAs (miRNAs). However, applying biochemical methods to understand such interactions in living tissues is major challenge. Here …
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Elucidating The Direct Role of M6A In The Human Transcriptome
<p>The best characterized and most abundant internal RNA modification is the methylation of adenosine at position 6 to give N6-methyladenosine (m6A). m6A modification on cellular RNAs was discovered in the 1970s. The past decade has witnessed major progress that illustrated important roles of this …
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Investigating processing body condensation, material properties and function during early Drosophila development
… biomolecular condensates which act as hubs for RNA regulation including storage, translation, and degradation. During Drosophila oogenesis, several maternal mRNAs are stored and translationally repressed inside P bodies before they are translated and degraded in the early embryo. How P bodies …
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Regulation of Immunoglobulin Gene Diversification By Noncoding RNA's
<p>Small regulatory RNAs supplement the canonical pathways of gene regulation through diverse mechanisms of transcriptional, post-transcriptional, and post-translational silencing. These mechanisms range from "classical" RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to …
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Mechanisms of Microbial DNA Sensing by the AIM2 Inflammasome and Structural Study of Polynucleotydyl Transferase1 (pnt1) from Arabidopsis Thaliana
… processes in SAM by repressing two miRNAs, miR166/165, and bind to these two miRNAs. Sequence analysis of PNT1 showed that it belongs to DnaQ-like 3'-5' exonuclease family, and hypothesized to be involved in RNA regulation with AGO10. PNT1 was purified and strong 3?-5? exonuclease …
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New Tools for Measuring and Analyzing Bacterial Gene-Expression Dynamics
Messenger RNAs (mRNAs) are essential targets of gene regulation. The cell adapts and grows by changing its gene-expression profile, which it can achieve by manipulating the rates of mRNA initiation and decay and thus changing the relative abundances of transcripts. To understand the biological …
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Simple Physical Approaches to Complex Biological Systems
… A second model is used to analyze the direct RNA interference mechanism the cell employs to tune the available gene transcripts of the master regulatory protein, i.e. small RNA - messenger RNA regulation. This model provides a possible explanation for puzzling experimentally measured …
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The Development of New Tools to Investigate Alphavirus Replication Kinetics
… nature by transmission cycles that involve alternating replication in a susceptible vertebrate and invertebrate host. The maintenance of this transmission cycle depends on the establishment of a life-long persistent infection in the invertebrate vector host. Although alphavirus replication has …
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Investigating the Molecular Mechanisms Underlying Ku Essentiality in Human Cells
… maintenance, the cell cycle, and transcriptional regulation. Despite Ku’s conservation across mammalian species, Ku is essential for human cell viability but is dispensable in mice. Essentiality in human cells was previously suggested to be due to Ku’s role in maintaining human telomere length. To …
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RNA Deregulation in Metastatic Breast Cancer
… modification of gene expression at the RNA level contributes substantially towards gain of metastatic potential. In eukaryotic cells RNA is subject to multiple layers of regulation that together generate extensive phenotypic and temporal complexity from a relatively small number of …
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Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants
MicroRNAs (miRNAs) are small, non-coding RNAs with a key role in regulating gene expression at post-transcriptional level. Recent investigations suggested that dysregulation in miRNA expression may be critical for mental disorders pathophysiology, including mood disorders, and in psychotropic drugs …
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Relationships between chromatin features and genome regulation
Regulation of gene expression is an essential process for all living organisms. Transcriptional regulation, associated with chromatin, is governed by: (1) DNA sequence, which creates regulatory sites (promoters, enhancers and silencers), where sequence motifs and features (e. g. CpG) can attract …
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The functional microRNA landscape of mammalian development
MicroRNAs (miRNAs) constitute a class of ~22 nucleotide RNAs with broad regulatory roles in gene expression. Dependent largely on the enzyme Dicer for their generation from longer precursor transcripts, mammalian miRNAs direct posttranscriptional repression of mRNAs based on complementarity to …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
<p>MicroRNA (miRNA) are small, non-coding RNAs that affect gene expression through degradation of complementary mRNA targets or inhibition of translation. As they affect approximately 50% of all cellular processes, miRNA are tightly regulated by the cell through transcriptional and …
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RNA Dynamics in T Cell Activation
… tune gene expression programs in response to external signals. Regulation of messenger RNA and microRNA by RNA-binding proteins is critical to the control of this process. Hence, disruptions of RNA regulatory processes result in neurologic diseases, cancer, and immunologic disorders among other …
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Genome-Wide Human-Specific RNA Regulatory Elements in the Brain
… better understanding of individual variation and regulation at the transcript level. Identifying the root cause of diversity between humans and specifically in the human brain has been a long-standing question for the scientific field. At the turn of the 20thcentury, Santiago Ramón y Cajal …
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Novel RNA Targets of the Spinal Muscular Atrophy Protein
… and the spliceosome which catalyzes pre-mRNA splicing. The biogenesis of RNPs often involves complex and elaborate pathways involving post-translational modifications, transit into specific cellular domains, and several auxiliary factors including assembly chaperones. One of the …
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Quantitative mRNA detection with advanced nonlinear microscopy
… information on quantity and localization of key mRNA transcripts in single-cell level are critical to the assessment of cancer risk, therapy efficacy, and effective prevention strategies. While current techniques are not capable to visualize single mRNA transcript beyond the diffraction limit. In …
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