Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"RNA polymerase mutations"”.
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Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations
… partially double-stranded, 5′-triphosphorylated RNA structure that is formed by the protein-free 3′ and 5′ termini (viral promoter) of viral genomic segments as well as aberrant replication products. However, it remains unknown how RIG-I gains access to the viral promoter when it is bound by the …
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Investigating the Double-Edged Sword of Rifampicin Resistance in Mycobacterium Tuberculosis
… taken for six to nine months. RifR is caused by mutations in rpoB, the gene encoding the β subunit of RNA polymerase (RNAP), the target of Rif. These mutations block Rif binding but also alter the shape of the RNA exit channel, potentially disrupting transcription elongation. As is true for many …