Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"RNA polymerase II C-terminal domain"”.
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Structural principles governing kinase specificity towards RNA polymerase II C-terminal domain and their impact on transcription
… (DNA) into a temporarily stored information (RNA). To orchestrate, selectively regulate and control this conversion, cells have evolved a variety of tools – the most interesting being the CTD of Pol II. The CTD sequence consists of seven amino acids repeated multiple times (Up to twenty-six …
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The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… by mediating the phosphorylation of Ser2 on the RNA polymerase II C-terminal domain. Using a cutting-edge PROTAC approach targeting BRD2, BRD3, and BRD4, in vivo studies showed impaired growth of ARID1A-depleted tumours and a reduction in metastatic burden. Further investigations in other tumour …
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Novel Algorithms for Automated NMR Assignment and Protein Structure Determination
… applied to solve the NMR structures of the FF Domain 2 of human transcription elongation factor CA150 (RNA polymerase II C-terminal domain interacting protein), which have been deposited into the Protein Data Bank. Second, we propose an automated side-chain resonance and NOE assignment …
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Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
… two separate pieces of work pertaining to pre-mRNA splicing in mammalian cells. The first part examines the regulation of the alternative splicing of the PKM gene in cancer cells, while the second part investigates the physical connections between the transcriptional apparatus and splicing …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… protein following prolonged TNFα stimulation. RNA sequencing analysis of wild-type, IKKα KO, IKKβ KO and IKKα/β DKO cells stimulated with TNFα was performed to identify genes whose expression were differentially deregulated by IKK KO. These analyses confirmed the importance of IKKα for …
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Epigenetic Regulation of Replication-Dependent Histone mRNA 3 End Processing
… Ser/Thr-Kinase, phosphoryliert die C-terminale Domäne der größten RNA Polymerase II (RNAPII)-Untereinheit an Serin 2. Diese posttranslationale Modifikation reguliert die Aktivität der RNAPII im Anschluss an die Transkriptionsinitiation. Darüber hinaus wird CDK9 ebenfalls eine …