Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 170 for “"RNA polymerase II"”.
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RNA polymerase II holoenzyme components and regulation
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Yeast and mammalian RNA polymerase II holoenzymes
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Regulation of yeast RNA polymerase II holoenzyme transcription
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
… programs. Understanding the dynamics by which RNA Polymerase II precisely induces transcription to activate these programs is important for dissecting the basis for their role in cell fate responses and disease progression. Here, we utilize high-resolution genomic approaches coupled with …
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Regulation der RNA-Polymerase II Transkription durch humanen Mediator
… Genen wird in Eukaryonten durch RNA-Polymerase II und die Generellen Transkriptionsfaktoren, die an den Promotor eines Klasse II Genes binden, bewerkstelligt. Eine Regulation der Aktivitaet dieser molekularen Maschine erfolgt durch Aktivator- und Repressorproteine, die …
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RNA Polymerase II control in the changing transcriptional landscape
Eukaryotic RNA polymerase II (Pol II) is a 12 subunit complex responsible for transcribing all protein coding genes, as well as producing many other RNA species. Regulation of gene expression is essential for the viability of any organism, and it is primarily achieved at the transcriptional level. …
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Structural and biochemical characterization of RNA polymerase II transcription
… One such mechanism involves pausing of RNA polymerase II (Pol II) in the promoter-proximal region of genes. Pausing is stabilized by the protein complexes DRB-sensitivity inducing factor (DSIF) and negative elongation factor (NELF). Prior structural and biochemical studies provide …
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Sumoylation of RNA Polymerase II Regulates Transcription in Saccharomyces cerevisiae
… reported that Rpb1, the largest subunit of RNA polymerase II (RNAPII), is sumoylated following UV-stress, our lab has shown that Rpb1 is also sumoylated under normal growth conditions. Here, we show that sumoylated Rpb1 is mostly associated with chromatin, providing further support for its …
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Regulation of Transcription Through RNA Polymerase II Promoter-Proximal Pausing
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Molecular genetic analysis of a yeast RNA polymerase II holoenzyme
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Eukaryotic RNA Polymerase II start site detection using artificial neural networks
… process for Eukaryotic ribonucleic acid (RNA) Polymerase II Promoter is presented in this dissertation. We employ an artificial neural network (ANN) in conjunction with features that were selected using an information-theoretic approach. Firstly an introduction is given where the problem …
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Functional antagonism of the RNA polymerase II holoenzyme by negative regulators
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Isolation and functional characterization of cofactors of RNA polymerase II transcription
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Regulation Of Transcription By RNA Polymerase II In <i>S. pombe</i>
… thesis research focusses on an analysis of the RNA Polymerase II elongation factor Ell1/Eaf1 in <i>S. pombe</i>. Eleven-nineteen lysine-rich in leukemia (ELL) is encoded by a gene involved in translocations with MLL in leukemia and forms a tight complex with ELL-associated factors (EAF). ELL/EAF …
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An Alternative View of the Templates and Functions of RNA Polymerase II
<p>RNA polymerase II (pol II) has been implicated in the RNA-templated RNA synthesis during replication of some Viroids and Hepatitis Delta Virus (HDV). In this study HDV RNA-templated pol II transcription was examined in vitro, using HeLa cell nuclear extracts (NE). Under standard conditions for …
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Mechanisms of recruitment of the CTD phosphatase Rtr1 to RNA polymerase II
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit Rpb1 must exist in a hypophosphorylated state prior to forming a competent transcription initiation complex. However, during transcription, specific kinases and phosphatases act on the RNAPII CTD to regulate its phosphorylation …
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Functional divergence of the RNA polymerase II transcription machinery in Plasmodium falciparum
… orthologue of general transcription factor IIB (TFIIB). Through the biochemical characterisation of protein-DNA interactions, protein-protein interactions and the biomolecular condensation properties of these transcription factors, this study aimed to provide insight into the molecular …
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