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Showing 1 to 20 of 409 for “"RNA polymerase"”.
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[RNA polymerase ribozymes]
The RNA World is a hypothetical ancient evolutionary era during which RNA was both genome and catalyst. During that time, RNA was the only kind of enzyme yet in existence, and one of its chief duties was the replication of RNA. This scenario presupposes that among all possible RNA sequences, there …
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Cryo-EM Studies of Bacterial RNA Polymerase
<p>In bacteria, a single RNA polymerase (RNAP) performs all transcription. The overall structure of bacterial RNAP resembles a crab claw with pincers comprising the β' and β subunits and a large cleft where the active site sits. Structural information about this essential enzyme has mainly been …
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Structural and Computational Studies of RNA Polymerase
<p>Although the multi-subunit RNA Polymerase (RNAP) structures have revolutionized our understanding of transcription, we still do not fully understand the molecular details of bacterial promoter recognition and melting. In addition, our understanding is generally limited to highly conserved …
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RNA polymerase II holoenzyme components and regulation
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Yeast and mammalian RNA polymerase II holoenzymes
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Molecular analysis of cyanobacterial RNA polymerase genes
The RNA polymerase genes rpoBC1C2 (the rpoB and rpoC2 are incomplete) of the cyanobacterium Nostoc commune have been cloned, sequenced, and expressed both in vivo and in vitro using E. coli systems. The rpo genes encode large subunits of DNA-dependent RNA polymerase. Two genes in N. commune, rpoC1 …
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Regulation of yeast RNA polymerase II holoenzyme transcription
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
… programs. Understanding the dynamics by which RNA Polymerase II precisely induces transcription to activate these programs is important for dissecting the basis for their role in cell fate responses and disease progression. Here, we utilize high-resolution genomic approaches coupled with …
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Regulation der RNA-Polymerase II Transkription durch humanen Mediator
… Genen wird in Eukaryonten durch RNA-Polymerase II und die Generellen Transkriptionsfaktoren, die an den Promotor eines Klasse II Genes binden, bewerkstelligt. Eine Regulation der Aktivitaet dieser molekularen Maschine erfolgt durch Aktivator- und Repressorproteine, die …
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RNA Polymerase II control in the changing transcriptional landscape
Eukaryotic RNA polymerase II (Pol II) is a 12 subunit complex responsible for transcribing all protein coding genes, as well as producing many other RNA species. Regulation of gene expression is essential for the viability of any organism, and it is primarily achieved at the transcriptional level. …
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Structural and biochemical characterization of RNA polymerase II transcription
… One such mechanism involves pausing of RNA polymerase II (Pol II) in the promoter-proximal region of genes. Pausing is stabilized by the protein complexes DRB-sensitivity inducing factor (DSIF) and negative elongation factor (NELF). Prior structural and biochemical studies provide …
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Sumoylation of RNA Polymerase II Regulates Transcription in Saccharomyces cerevisiae
… reported that Rpb1, the largest subunit of RNA polymerase II (RNAPII), is sumoylated following UV-stress, our lab has shown that Rpb1 is also sumoylated under normal growth conditions. Here, we show that sumoylated Rpb1 is mostly associated with chromatin, providing further support for its …
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Regulation of Transcription Through RNA Polymerase II Promoter-Proximal Pausing
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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In vivo studies of repressors of RNA polymerase III transcription
RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of genes, including 5S rRNA and tRNAs. Pol III transcription has been shown to be upregulated in transformed and cancer cells, suggesting an important role in cell growth and proliferation. Its tight …
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Characterization of the Omega Subunit of Borrelia Burgdorferi’s RNA Polymerase
… changes in gene expression carried out by RNA polymerase (RNAP). The RNAP holoenzyme consists of two ɑ subunits, a β subunit, and a β’ subunit. Additional proteins have been implicated in the function of RNAP including RpoZ (i.e. omega subunit, ω). Investigations of RpoZ homologues from …
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Molecular genetic analysis of a yeast RNA polymerase II holoenzyme
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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