Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RNA packaging"”.
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Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses
It was previously thought that the RNA structural elements within the 5’UTR were the sole determinants of RNA packaging in HIV-1. However, in 2013 Chamanian et al. discovered that the region overlapping the Ribosomal Frameshift Signal (RFS) acted to enhance RNA packaging 50 fold and was thus named …
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Investigating the mechanism of RNA packaging in Rift Valley Fever phlebovirus
… a trisegmented, single-stranded, negative-sense RNA genome, consisting of L, M and S segments. The virion carries two envelope glycoproteins, Gn and Gc, along with ribonucleoprotein complexes (RNPs), composed of encapsidated genomes carrying the nucleocapsid protein, N, and the RNA-dependent RNA …
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A Novel HIV-1 Genomic RNA Packaging Element and its Role in Interplay between RNAPackaging and Gag-Pol Ribosomal Frameshifting
Retroviruses belong to a diverse family of RNA viruses that utilize the eukaryotic translational machinery for viral protein synthesis during infection of its target cells. In the cytoplasm, the unspliced version of retroviral RNA takes one of two pathways: 1) to serve as mRNA template for Gag …
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Mechanisms of retroviral replication
Specific encapsidation of viral RNA is an essential step of retroviral replication cycle. Extensive biochemical and genetic analyses suggest that majority of retroviruses employ similar mechanisms for specific RNA packaging. Better understanding of mechanisms of this process may help to develop new …
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… leader region (5'UTR) of HIV genomic RNA is essential for understanding viral replication because the 5'UTR regulates several essential functions by the alternate presentation and sequestration of signals through conformational changes. Our main focus in this study was to understand …
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STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA
… leader region (5'UTR) of HIV genomic RNA is essential for understanding viral replication because the 5'UTR regulates several essential functions by the alternate presentation and sequestration of signals through conformational changes. Our main focus in this study was to understand …
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The broken genome: Merging cutting edge technologies for a molecular understanding of the Flock House virus defective interfering particle.
Defective RNAs are natural versions of a viral genome that have been truncated or rearranged by non-homologous recombination. While not encoding for functional viruses, they can be amplified and co-passaged with the wild-type virus, effectively parasitizing the normal viral machinery. Some …
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Statistical thermodynamics of virus assembly
… of HIV-1 capsids. Secondly, the problem of RNA genome packaging inside spherical viruses is studied using RNA condensation theory. For weak adsorption strength of capsid protein, most RNA genomes are located at the center of the capsid. For strong adsorption strength, RNA genomes peak near …