Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"RNA methylation"”.
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An Inverse Electron-Demand Diels-Alder Strategy for Mapping RNA Methylation
Post-transcriptional RNA modifications, such as N6-methyladenosine (m6A), 2'-O-methylation (Nm), and 5-methylcytosine (m5C), are critical regulators of gene expression. Mapping these modifications at single-nucleotide resolution, however, remains a major challenge as current methods often suffer …
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Investigating the impact of pharmacological exposures on the developing epigenome
… DNA methyltransferases (DNMTs), removal of DNA methylation and induction of DNA damage. I show that treatment of mouse embryonic stem cells (mESCs) with 5-azacytidine and decitabine, whilst both causing DNA hypomethylation, leads to differing effects on imprinted gene expression and long-term …
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RNA modifications and processing in cell homeostasis and in response to oxidative stress
RNA modifications and processing events are important modulators of global gene expression. Genomic mutations in the RNA methylase NSun2 and the alternative splicing factor Srsf2 are linked to neurological disorders and cancer in humans, respectively. NSun2 methylates cytosine-5 in most tRNAs and, …
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Modulation of RNA Cytosine-5 Methylation by Neuronal Activity and Methyl-donor Folate
RNA epigenetics or Epitranscriptomics has emerged as a new field for understanding the post-transcriptional regulation of gene expression by RNA modifications. Among numerous types of RNA modifications, RNA cytosine-5 methylation (5-mrC) is recognized as an important epitranscriptomic mark that …
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Regulation of yeast development by mRNA methylation
The internal methylation of mRNA post-transcriptionally is an essential component of the mRNA editing machinery in virtually every eukaryotic system. Despite this ubiquity, little is known about the relevance, consequences or machinery involved in this process. The recent demonstration of this …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… stress signalling response, the contribution of RNA-based regulatory layers has remained largely unexplored. This study identifies an unexpected role for N6-methyladenosine (m6A) RNA methylation as an essential post-transcriptional determinant of p53 activation in response to centrosome-derived …
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STRUCTURAL AND FUNCTIONAL STUDIES OF ARCHAEAL BOX C/D GUIDE RNA AND ROLE OF A PUTATIVE HUMAN PSEUDOURIDINE SYNTHASE, PUS10 IN APOPTOSIS
RNAs undergo different posttranscriptional chemical modifications, which affect their structural stability and functional diversity. RNA methylation is a very common type of post-transcriptional modification and is present in all domains of life: Archaea, Eukaryotes and Bacteria. Some of these …
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Role of Methyltransferase Like-3 (Mettl3) In Pancreatic Ductal Adenocarcinoma (Pdac) Progression
… effect, METTL3-mediated post-transcriptional methylation of RNA transcripts have been shown to contribute to cancer progression in multiple cancer types.</p> <p>METTL3 deposits methyl groups onto adenosine bases within specific consensus sequences in RNA, resulting in the formation of N-6 …