Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"RNA metabolism"”.
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Rna Metabolism of Phage Infected Protoplasts
Made available in DSpace on 2014-12-05T21:45:31Z (GMT). No. of bitstreams: 1 5904489.pdf: 3862437 bytes, checksum: 71fdf36b2a559646088a160e5e6077d9 (MD5) Previous issue date: 1959
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Functional Roles of Nova in RNA Metabolism
<p>Nova-1 is a neuron-specific RNA binding protein, distributed both in the nucleus and the cytoplasm of several populations of neurons. The work presented here confirms that Nova-1 binds a sequence of RNA found in an intron of the glycine receptor a2 subunit pre-mRNA. Evidence that Nova-1 acts as …
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Crosstalk between DNA end resection and RNA metabolism
… crosstalk between DNA Damage Response (DDR) and RNA metabolism at different levels has been discovered. Thus, in this Thesis we studied this relationship deeply. We described that the splicing complex SF3B is involved in in DNA damage repair. Although part of such function is through CtIP, we …
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Terminal uridyl transferases: TUT4/7-mediated RNA metabolism in cancer
Nascent RNA is subjected to a wide range of RNA metabolic processes such as non-templated additions of uridines at the 3′ end after it has been transcribed. These additions are catalysed by the terminal uridyl transferases TUT4 and TUT7 (TUT4/7). Defects in TUT4/7-mediated functions result in …
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Effects of BRCA1-Mediated Ubiquitination of HuR on RNA Metabolism in Breast Cancer
… dissertation examines the ubiquitination of the RNA binding protein Human antigen R (HuR) by BRCA1/BARD1 and the implications of this ubiquitination event on gene expression in breast cancer.</p> <p>HuR binds to mRNA targets in the nucleus and escorts them to the cytoplasm, typically stabilizing …
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Structures and Regulation of the N6-Methyladenosine Methyltransferase METTL16
Chemical modifications of RNA control the abundance and function of both coding and non-coding RNA molecules. The most abundant mRNA modification is N6 methyladenosine (m6A), which has been shown to regulate RNA splicing, translation and decay. The m6A modification is deposited by …
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Functional characterization of the RNA binding protein RALY
… from genome, more than 90% are subject to alternative splicing or other post-transcriptional modifications. All these events produce a high number of different proteins that form the basis for the high variety of cells. The RNAbinding proteins (RBPs) play crucial roles in this variability by …
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Synchrony of harmony and chaos in a dynamic, bacterial riboregulatory machine
… of life, proteins involved in the regulation of RNA lifetimes are often found to form multi-enzyme complexes, suggesting a common requirement to colocalise their activities to meet the demands of RNA metabolism 1,2. In diverse bacterial lineages, these multi-enzyme complexes, referred to as “RNA …
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A DE NOVO COMPUTATIONAL DISCOVERY PLATFORM FROM RNA TO PROTEIN
… regulation mechanisms hugely increase RNA isoform diversity, while their contribution to protein synthesis remains vastly unexplored. Moreover, the transcriptome composition changes in different human cell types, tissues, and conditions. Therefore, there is great need for unbiased, …
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TOWARDS AN UNDERSTANDING OF GENETIC SELECTION IN BREAST CANCER
… DNA packaging, cellular component assembly, RNA metabolism and regulation of apoptosis. Stable genes were consistently found to be targets of therapeutic drugs. Conservation of this minimal gene set may explain the effectiveness of certain chemotherapeutic agents that act on multiple gene …
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Genetic and biochemical analysis of a conserved DEAD-box helicase motif
… that use ATP to power unwinding of short RNA duplexes in essential steps of RNA metabolism. Despite acting on a diverse range of RNA substrates, DEAD-box proteins share a helicase core defined by 13 highly conserved amino acid motifs. Here we use S. cerevisiae Mss116p, a mitochondrial …
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HAGE, a novel cancer/testis antigen with strong potential as a target for immunotherapy against cancers
… in several carcinomas and leukaemias at the mRNA level only. This study proposed to investigate HAGE as a potential target for immunotherapy in a murine tumour model. HAGE mRNA was found to be expressed in a small proportion of carcinomas, some melanomas and in a strong proportion of chronic …
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Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation
TDP43 is an ubiquitously expressed RNA-binding protein implicated in several aspects of RNA metabolism. It can shuttle between the nucleus and the cytoplasm; however, when it is mutated in some familial Amyotrophic Lateral Sclerosis (ALS) cases, it undergoes nuclear clearance and cytoplasmic …
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Investigating the function and mechanistic control of processing bodies in early Drosophila melanogaster development
… mechanism by which cells can organise their internal environment. These cellular compartments are described as a mesoscopic concentration of biological macromolecules that are physically segregated from the rest of the cytoplasm or nucleoplasm, despite the lack of a limiting membrane. This …
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Biochemical Analysis of Evolutionary Divergent Vertebrate Larp6 Proteins
… proteins (LARPs) contain a conserved bipartite RNA binding domain, called the La module, which consists of the La motif and an RNA recognition motif (RRM). Across the LARP subfamilies, the La module interacts with a variety of RNAs, allowing this protein superfamily to perform roles as chaperone …
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Functional analysis of amyotrophic lateral sclerosis mutations using Drosophila cell culture models
… potential therapeutic targets for ALS. Bulk RNA sequencing was employed to investigate transcriptomic changes in Drosophila S2R+ cells expressing TDP43 wild-type and mutant. Differential gene expression and pathway analysis revealed dysregulation in RNA metabolism, mitochondrial function, and …
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Multiple Levels of Regulation of Cyclin-dependent Kinase Inhibitor 1A (p21/WAF-1) by the <i>DDX5 </i>Gene
… an archetypical member of the DEAD box family of RNA helicases, exhibits both ATPase and RNA helicase dependent/independent activities. To date the p68 protein has been implicated in most parts of RNA metabolism including ribosome biogenesis, transcription, RNA decay, miRNA processing and pre-mRNA …
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The Effect of Stress Induced Premature Senescence on the Expression of Heterogeneous RibonucleoIeoprotein
… the senescence phenotype. hnRNPs are a family of RNA binding proteins that play key roles in various metabolic functions of the RNA such as splicing. hnRNP A1 in addition to its biochemical functions in RNA metabolism can bind to mRNAs for transport through the nuclear envelope. Our studies have …
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Sequence-Based Properties that Identify Intrinsically Disordered Phase-Separating Protein Regions
… critical in many cellular processes (including RNA metabolism, chromatin rearrangement, and signal transduction), and known to be driven primarily, but not exclusively, by IDPs. To fully understand how these processes occur and are regulated, it is important that we understand the interactions …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
… H3k04 dimethylation had mutations in noncoding RNA processing and RNA metabolism in common. By the functional analysis from mutation studies of liver cancer, the profile of each subgroup was compared, and the functions related to tumor malignancy could be found.
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