Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"RNA labeling"”.
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Development of site-specific RNA labeling strategies to probe alternative RNA splicing
… of this project was to develop a method for the labeling of RNA at specific locations using non-natural base pairs. This thesis details the efforts made towards this objective through the development of a modular synthetic platform for an expanded genetic alphabet and its evaluation using …
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Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
… conducted the first genome-wide, imaging-based siRNA screen to identify regulators of LAD positioning using HiDRO (high-throughput DNA or RNA labeling with optimized Oligopaints). Completion of the screen led to the identification of 101 genes required for proper perinuclear localization. …
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Developing high-resolution methods to study DNA and RNA dynamics
Nucleic acids, including DNA and RNA, are one of the most important biomacromolecules inside the cell. DNA stores genetic information, while RNA has more versatile roles including conveying and deciphering genetic information, catalyzing biological reactions, conducting post- transcriptional …