Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"RNA helicase"”.
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CHARACTERIZATION OF THE FUNCTION OF THE DEAD-BOX RNA HELICASE DBP2
… there are highly coupled mechanisms that require RNA-binding proteins to facilitate gene expression. Proper RNA structure and ribonucleoprotein (RNP) complex formation are critical for gene expression. DEAD-box proteins are the largest class of RNA helicases that play fundamental roles in RNA and …
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Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
… AT AUTHOR'S REQUEST.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs in the miRNA pathway, have been shown to be interdependent in the C. elegans germline. The work described here is based on …
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
… (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain switch (S) regions in the DNA for CSR. Sequence alignment revealed homology between the AID G4 binding domain and the RNA helicase associated with AU-rich element (RHAU) specific motif (RSM), …
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RNA helicase MOV10 is essential for gastrulation and normal CNS development
… we demonstrated that FMRP associates with the RNA helicase Moloney Leukemia Virus 10 (Mov10) in brain and modulates its translational activity through the microRNA (miRNA) pathway. FMRP is critical for normal cognition and our findings hypothesize a role for Mov10 in brain function. …
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RNA Helicase 1 interacts with an ABCRNAi Transporter: Genetic Interactions with haf-6
The C. elegans rha-1 gene encodes a conserved helicase with ATP-dependent DEAD/H-box and double-stranded RNA binding domains. rha-1 is orthologous to the Drosophila maleless gene(MLE), an essential component of the dosage compensation machinery that leads to a two-fold increase in transcription of …
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Investigation of the roX RNAs and the RNA Helicase MLE in Dosage Compensation in Drosophila melanogaster
… and is composed of the two noncoding roX (RNA on the X) RNAs and at least five proteins, including the RNA helicase Maleless (MLE). MLE contains two highly conserved double stranded RNA binding domains (DRBDs) at the N terminus. We investigated the roles of the roX RNAs and MLE helicase …
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Nuclear binding and translation regulation by FMRP through novel associated protein and putative RNA helicase MOV10
… of FMRP has not been widely studied. FMRP is an RNA binding protein that is important for normal neuronal development and maturation as well as proper cognitive development as the lack of FMRP results in fragile X syndrome (FXS). I next move out of the nucleus and study the role of FMRP and …
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Molecular requirements for FMRP and RNA helicase MOV10 in the translational regulation of co-bound mRNAs
… (FMRP), regulates translation of its bound mRNAs through an incompletely defined mechanism. Historically, FMRP has been known to directly associate with Argonaute (AGO), a key effector protein of the RNA induced silencing complex (RISC). MicroRNAs regulate key cellular processes in mammalian …
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Dissecting the role of RNA helicase DDX3X in mRNA translation and B-cell function during immune responses
… of B-cell lymphomagenesis. Mutations in DEAD-box helicase 3X (DDX3X) have previously been found in B-cell lymphomas driven by the transcription factor MYC. Reduced DDX3X function buffers the effect of MYC on the upregulation of global translation, ultimately lowering the levels of proteotoxic …
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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1
… and cancer associated mutations of the DEAD-box RNA helicase DDX3X, homolog of fission yeast Ded1, in translational control. Heterochromatin in fission yeast is characterized by hypoacetylation as well as methylation of histone H3 on lysine 9 (H3K9me). Heterochromatin assembly can now be …
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The Role of Coregulator Proteins in Nuclear Receptor Transcriptional Activity
… in which I have characterized a novel DEAD box RNA helicase as a nuclear receptor coregulator. I have also examined the similarities in the actions of ERalpha and ERbeta using large-scale chromatin arrays and ER subtype-selective ligands.
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… novel affinity purification method. The DEAH-box RNA helicase DHX16, a pre-mRNA splicing factor, was identified as a new unanchored poly-Ub-interacting factor. Silencing of DHX16 in cells and in vivo diminished IFN-I responses against viruses from multiple families including influenza A (IAV), …
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The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
The human DEAD-box RNA helicase DDX3X has previously been shown to be involved in innate immune signalling in pathways mediated by IKKε and TBK1. In this work we show that DDX3X is also involved in pathways independent of these kinases, and functions by interacting with two related kinases IKKα and …
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Molecular Characterization of Mth203 protein
… forms a hexameric complex and acts as a DNA helicase. What loads the archaeal MCM helicase and how DNA replication initiation is regulated is still unknown. Mth203, a putative RNA helicase in M. thermautotrophicus has been shown to interact with MthCdc6-1 in a yeast two-hybrid screen and …
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Molecular characterization of Mth203 protein
… forms a hexameric complex and acts as a DNA helicase. What loads the archaeal MCM helicase and how DNA replication initiation is regulated is still unknown. Mth203, a putative RNA helicase in M. thermautotrophicus has been shown to interact with MthCdc6-1 in a yeast two-hybrid screen and …
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Characterization of PRD-1 Mutation in Neurospora crassa
… a mutation that affects the splicing of the mRNA. The identity of the gene was confirmed by complementing the prd-1 mutant with a wild type copy of the identified candidate gene. The prd-1 gene is identified as an RNA helicase.
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Genetic Analysis of Rna Exosome Complex Cofactors
<p>The RNA exosome complex is known to process and/or degrade many classes of RNA, including mRNA, rRNA, tRNA and snRNA, through its 3’-to-5’ exoribonuclease catalytic activity. The RNA exosome complex comprises a 9-unit core (exo-9), with six proteins making up a PH-Ring barrel and three proteins …
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Tamarillo mosaic potyvirus: characterization and resistance
… in the fruit being unacceptable on the international marketplace. Virus incidence was surveyed in four tamarillo growing regions. Viruses were detected by indicator plant symptomology, and the incidence confirmed by dot blot analysis or ELISA. TaMV was present in 100% of tamarillo trees …
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Mutational analysis of the tobacco etch potyvirus cylindrical inclusion protein
… is known to be an NTPase as well as a putative RNA helicase. In a previous study, the CI gene and three mutants were constructed and expressed in the E. coli expression vector pET 11a. In this study the TEV CI gene was cloned into E. coli expression vector pET 15b and five other mutants were …
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