Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"RNA export"”.
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RNA EXPORT FACTOR ELF1 MAINTAINS GENOME STABILITY IN FISSION YEAST
… that Elf1, a AAA+ family ATPase involved in mRNA nuclear export, prevents genome instability. Upon deletion, elf1Δ cells grow slowly, forming small colonies. Curiously, they can switch to larger, faster-growing colonies. Genetic analysis revealed that frequent mutations, rather than prions or …
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New Roles in RNA Stability and Transcription for the RNA Export Protein, REF/Aly
Pre-mRNA processing consists of a series of events including capping, splicing, and polyadenylation, which occur co-transcriptionally, are interdependent, and are coupled to other steps in gene expression including transcription and RNA export. For example, in mammalian cells the TREX …
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Tap /Nxf1 N -Terminal Domain Mediates Homotypic Complex Assembly and Is Necessary for Nuclear RNA Export
Tap/NXF1 is the metazoan nuclear export receptor for both poly (A+) RNA as well as cellular and viral RNAs containing the constitutive transport element (CTE). Tap is a multi-domain protein that interacts directly with nucleoporin proteins of Nuclear Pore Complexes (NPCs) as well as messenger RNA …
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Die Rolle von eIF-5A und Kernaktin bei Kernexportprozessen
… in der eukaryotischen Zelle erfordert den Export Intron-enthaltender Transkripte aus dem Kern ins Cytoplasma. Bei HIV-1 wird dieser nucleocytoplasmatische Transport durch den viralen Transaktivator Rev vermittelt. Rev ist ein Shuttle-Protein, das sowohl ein Kernimportsignal (NLS) als auch …
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Function and Mechanism of Alkbh5 In N6-Methyl-Adenosine Rna Modification In Glioblastoma
… (m<sup>6</sup>A) is the most prevalent internal chemical modification of mRNAs in eukaryotes. In mammals, m<sup>6</sup>A installed by m<sup>6</sup>A methyltransferases METTL3 and METTL14 is erased by two members of the AlkB family of nonheme Fe(II)/a-ketoglutarate (a-KG)-dependent …
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Cell cycle-dependent regulation of the human RNA cap methyltransferase (RNMT)
… gene expression including transcription, pre-mRNA processing, RNA export and translation. The N-7 methylguanosine cap is added co-transcriptionally to RNA pol II transcripts. In mammals, two enzymes catalyse the synthesis of the N7-methylguanosince cap. RNGTT adds an inverted guanosine group to …
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The effect of Coxsackie virus A9 infection on nuclear and nucleolar proteins
Picornaviuses replicate in the cytoplasm, but there is growing evidence that the cell nucleus is affected by infection e.g. transcription factor cleavage, relocation of nuclear proteins and alteration to nucleo-cytoplasmic shuttling. It was previously observed that Parechovirus genus members affect …
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A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease
… metabolism, protein synthesis, nuclear and RNA transport across the nuclear pore complex, apoptosis, and innate immune responses. Picornaviruses are the most dominant human disease-causing viruses and present an excellent clinical target for research studies into their molecular mechanisms. …
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Mechanisms of piRNA biogenesis and co-transcriptional silencing of transposable elements in Drosophila
… safeguard genome integrity. Among these is the piRNA pathway, a gonad-specific system based on small non-coding RNAs that recognise active transposons and instruct their silencing. Ultimately, piRNAs trigger epigenetic silencing of transposon loci. The work in this thesis investigates the …
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Investigating upstream regulators of FOXA1 in breast cancer
… several regulators, including NXF1, a nuclear RNA export factor. RNAscope analysis showed that NXF1 controls FOXA1 protein levels via regulation of FOXA1 mRNA nuclear export. Mechanistic experiments further revealed that NXF1 associates with nascent RNA co-transcriptionally on chromatin. …
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Role of DDX RNA helicases in cancer cells
Ester Cannizzaro ROLE OF DDX RNA HELICASES IN CANCER CELLS Abstract DEAD-BOX (DDX) RNA helicases are a large family of proteins characterized by the presence of a DEAD/H (Asp-Glu-Ala-Asp/His) motif. Their main function is to unwind double stranded RNA to promote downstream molecular events. They …
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Targeting Alternative Conformational States of the HIV-1 Rev Response Element Stem IIB using Small Molecules
<p>RNAs are growing in their importance as regulators in multiple biological processes. A deep understanding of how RNAs function within cells requires an understanding of their dynamic behavior to enable the targeting of RNA in drug discovery as therapeutics. The HIV-1 Rev response element (RRE) …