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Showing 1 to 10 of 10 for “"RNA exosome"”.
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Genetic Analysis of Rna Exosome Complex Cofactors
<p>The RNA exosome complex is known to process and/or degrade many classes of RNA, including mRNA, rRNA, tRNA and snRNA, through its 3’-to-5’ exoribonuclease catalytic activity. The RNA exosome complex comprises a 9-unit core (exo-9), with six proteins making up a PH-Ring barrel and three proteins …
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Identifying Subunit Organization and Function of The Nuclear Rna Exosome Machinery
… SUBUNIT ORGANIZATION AND FUNCTION OF THE NUCLEAR RNA EXOSOME MACHINERY </strong></p> <p><strong>Jillian Strother Losh, A.S., B.S. </strong></p> <p>The eukaryotic RNA exosome processes and degrades many classes of RNA. It is present in the nucleus and the cytoplasm, highly evolutionarily conserved, …
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Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
<p>The RNA exosome is an essential 3’-5 ribonuclease that processes or degrades a variety of RNA species in eukaryotes. It is composed of nine structural cores and one catalytic subunit, Rrp44. Structural studies captured two different conformations of Rrp44, Rrp44<sup>ch</sup> (channel) and …
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Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
<p>Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases</p> <p>Khondakar Sayef Ahammed, M.S.</p> <p>Advisory Professor: Ambro van Hoof, Ph.D.</p> <p><strong> </strong></p> <p>RNA maturation and degradation reactions are important for health and survival of all …
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Post Translational Regulation of AID Targeting to Both Strands of a Transcribed DNA Substrate
… such as R loops, transcription factors, miRNA, and phosphorylation as events important for determining AID's ability to access its substrate sequences. However, none of these studies demonstrated how AID mutates both strands of DNA, reminiscent to its in vivo mode of action.The focus of …
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Functions of Dcp2 and Ski7 In Mrna Degradation
… fidelity. This is partially achieved by mRNA decay. When no longer required, mRNA is degraded by two alternative pathways. The decapping enzyme Dcp2 removes the 5` <sup>m7</sup>G cap of mRNAs, allowing Xrn1 to degrade the mRNA from the 5` end. Alternatively, mRNA is degraded from the 3` …
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The regulation of premature termination at divergent promoters
… the conversion of genetic information to RNA. Numerous regulatory mechanisms function to ensure that desired transcripts are being expressed. Promoters transcribe divergently, producing low-abundant upstream antisense RNAs (uaRNAs) in addition to a stable downstream RNAs. Thus, a central …
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Identification and Molecular Analysis of Dna In Exosomes
<p>Exosomes are heterogeneous nanoparticles 50-150nm in diameter. Exosomes contain many functional cargo components, such as protein, DNA, and RNA. While protein and RNA exosome content has been extensively studied, very little work has been done to characterize exosomal DNA. Here, we demonstrate …
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The Role of The Arched Helicases In Exosome-Mediated Function
<p>RNA processing and degradation are two important functions that control gene expression and promote RNA fidelity in the cell. A major ribonuclease complex, called the exosome, is involved in both of these processes. The exosome is composed of ten essential proteins with only one catalytically …
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals in mouse embryonic stem cells
RNA polymerase II (RNAPII) transcription is a tightly regulated process controlling cell type and state. Advancements in our understanding of how transcription is regulated will provide insight into the mechanisms controlling cell identity, cellular differentiation, and its misregulation in …