Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"RNA editing"”.
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A-to-I RNA Editing in Human Cells
<p>RNA editing is a means of diversifying the transcriptome and regulating innate immunity. Among the different classes of enzymes that modify RNA, adenosine deaminase acting on RNA (ADAR) is a type that catalyzes adenosine-to-inosine editing on double-stranded RNA molecules to regulate cellular …
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SEQUENCE ELEMENTS ESSENTIAL FOR RNA EDITING IN CHLOROPLASTS
… are specifically edited to uridines. Almost all editing events lead to the restoration of a codon for a conserved amino acid instead of one predicted from the organelle genome. The sequences immediately surrounding an edited C are required for proper selection of the C target. There is no single …
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Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages
<p>RNA editing refers to the process by which the sequence of RNA is altered through the insertion, deletion or modification of specific nucleotides. Editing of mRNA transcripts can increase the informational complexity encoded by the genome by producing alternative protein isoforms through …
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An Investigation into Transformation and RNA Editing in the Lolium Plastome
… to be addressed. The present study is focused on RNA editing (post-transcriptional nucleotide modifications resulting in altered transcripts) within plastidial transcripts of the NDH complex (NADH dehydrogenase complex) in relation to the drought response of several accessions of perennial …
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Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro
<p>Adenosine deaminases acting on RNA (ADARs) convert adenosine-to-inosine in double stranded RNA. Selectivity of editing sites depends on the sequence of the RNA as well as the secondary structure. Identification of sites of ADAR editing by editome analysis is skewed due to the different abundance …
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Next-generation sequencing analysis and RNA editing in human brain and glioma
RNA sequencing (RNA-seq) is one of the most common technologies in use today for the analysis of gene expression and transcriptome variation in biological samples (Zhong Wang et al. 2009). As of 2011, the NCBI Sequence Read Archive (SRA) surpassed 100 terabases of sequence data, comprising nearly …
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RNA editing and mutagenesis of the soybean (Glycine max) mitochondrial atp9 gene
… proteins involved in organellar function. Maternal inheritance of some traits such as cytoplasmic male sterility (cms) in plants can be linked to mitochondrial DNA. However, further understanding of mitochondrial gene expression, regulation and DNA rearrangements has been hindered by the lack …
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Identification of RNA editing in the human exome and development of DARNED DatabaseSF
RNA editing is a biological phenomena that alters nascent RNA transcripts by insertion, deletion and/or substitution of one or a few nucleotides. It is ubiquitous in all kingdoms of life and in viruses. The predominant editing event in organisms with a developed central nervous system is Adenosine …
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RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA
ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA (DSRNA) (ADARS) IS A FAMILY OF ENZYMES CATALYSING ADENOSINE TO INOSINE CONVERSION (A-TO-I EDITING). IF HAPPENED IN CODING REGIONS, A-TO-I EDITING CAN CAUSE PROTEIN RECODING. RECODING EDITING HAS BEEN REPORTED TO CONTRIBUTE TO HEPATOCELLULAR …
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Alternative splicing and RNA editing of the Complexin C-terminus regulates neurotransmitter release in Drosophila
… assembly. The Drosophila cpx locus undergoes alternative splicing to produce two isoforms (Cpx7A and Cpx7B) that differ in the C-terminal ~20 amino acids of Cpx. Although PKA phosphorylation of Cpx7B C-terminal residue S126 enhances spontaneous release and synaptic growth in Drosophila, the more …
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Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
<p>Post-transcriptional modifications such as alternative splicing have been shown to add to the complexity needed to compensate for the relatively low number of genes found in higher organisms. Many other modifications recently found in mRNA, which cannot be deduced from what is coded in the …
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Knowledge bases and stochastic algorithms for mining biological data: applications on A-to-I RNA editing and RNAi
… di approcci stocastici sul targeting dei microrNA e il fenomeno dell'RNA interference.
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Characterization of the Role of Differential Gene Expression and RNA Editing in Drosophila Tonic and Phasic Motoneuron Diversity
… synaptic properties. First, we sequenced RNA from 105 Ib and 101 Is single neurons to define the transcriptome for each neuronal subtype. Comparison of gene expression levels revealed ~800 differentially expressed genes (DEGs) across multiple gene classes, including intracellular Ca²⁺ …
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Knowledge bases, computational methods and data mining techniques with applications to A-to-I RNA editing, Synthetic Biology and RNA interference
… meccanismi di regolazione post-trascrizionale ed RNA interference, così come il collegamento del fenomeno dell RNA A-to-I editing con la regolazione genica mediate dai miRNA. In particolare, gli sforzi sono stati finalizzati allo sviluppo di una banca dati per la predizione di siti di legame per …
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Mechanism of resistance to tyrosine kinase inhibitors in philadelphia-positive acute lymphblastic leukaemia (all): from genetic alterations to impaired RNA editing
… in the lymphoid lineages. By means of alternative splicing, Ikaros encodes several proteins that differ in their abilities to bind to a consensus DNA-binding site. Shorter, DNA nonbinding isoforms exert a dominant negative effect, inhibiting the ability of longer heterodimer partners to …
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