Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"RNA biogenesis"”.
-
Sequence and structure requirements of Y RNA-derived small RNA biogenesis
Numerous small non-coding RNAs have been identi�ed in mammalian cells, including microRNAs and piwi-interacting RNAs. The patterns of gene expression within cells can be altered in response to cellular stress. To examine the e�ects of cellular stress on all small RNA types, a number of human cell …
-
Human FRG1 is an Actin-Bundling and a RNA-Associated Protein with Distinct Subcellular Localizations
… transcribed chromatin associated with nascent RNA transcripts, supporting a function in RNA biogenesis. Furthermore, we show that FRG1 interacts specifically with RNA in vitro, associates with mRNA in vivo, and directly interacts with the TAP mRNA export receptor. FRG1 also exists in a …
-
Context Dependent Regulation of Dicer Function During Oocyte-to-Embryo Transition
… enzyme responsible for the generation of small RNAs known as the microRNAs (miRNAs) and short interfering RNAs (siRNAs). Spatiotemporal regulation of Dicer-dependent small-RNA biogenesis affects many aspects of biology, including aging, disease progression, fertility, and cancer. Interestingly, …
-
The Transposon-Encoded Protein TnpB is an RNA-Guided Nuclease
Programmable RNA-guided systems, such as CRISPR-Cas adaptive immune systems, perform a wide variety of biological functions and have been harnessed for important therapeutic and diagnostic biotechnologies. One CRISPR effector protein, the Cas12 nuclease, is hypothesized to have its evolutionary …
-
The Biogenesis of Small Interfering RNA in Neurospora Crassa
RNA interference is a well-conserved gene silencing mechanism in eukaryotes. It regulates various biological processes including development, genome defense and heterochromatin formation. RNAi is initiated by the production of dsRNA, which is processed by Dicer to produce small interfering RNA …
-
High Throughput Detection of Pseudouridine: Caveats, Conundrums, and a Case for Open Science
… post-transcriptional modification of stable RNAs. Due to technical limitations in pseudouridine detection methods, studies on pseudouridylation have historically focused on ribosomal RNAs, transfer RNAs, and spliceosomal small nuclear RNAs, where Ψs play a critical role in RNA biogenesis and …
-
RNA in the nucleus: insight into location and biological function
RNA is an important constituent of the nucleus with functions including regulation of RNA biogenesis, regulation of gene expression, and dosage compensation. Currently used technologies to study RNA chromatin interactions pull down individual RNAs and sequence the associated DNA. However, it …
-
Elucidating the functions of RNA helicases DDX3X and DDX3Y in normal and malignant B cells
DDX3X is an RNA helicase involved in multiple stages of RNA biogenesis, the most well-studied being as a regulator for translation. Its Y chromosome paralogue, DDX3Y shares 92% amino acid conservation. DDX3X is ubiquitously expressed and considered pan essential. While DDX3Y is widely transcribed, …
-
A Census of Human RNA-Binding Proteins and Characterization of the DEDDh RNA Exonuclease NEF-sp in the 3' End Maturation of 28S Ribosomal RNA
… acting directly upon coding and non-coding RNAs, regulating and executing their maturation, ribonucleoprotein assembly, transport, stability and translation. RNA-binding proteins (RBPs) and ribonucleoprotein (RNP) complexes coordinate these processes. RBPs are central to cellular metabolism …
-
Dynamic changes of TDP-43 in testicular and epididymal sperm
… conserved protein. TDP-43 is a DNA/RNA binding protein with several functions such as gene transcription, mRNA splicing and stability, transposon silencing, and micro RNA biogenesis. TDP-43 is associated with many neurodegenerative disorders, including amyotrophic lateral sclerosis …
-
SR proteins in microRNA/mRNA biogenesis
… in the regulation of both constitutive and alternative splicing of pre-mRNAs. Despite years of studies, several big questions still remain: how the expression levels of SR proteins are regulated; what are the underlying mechanisms responsible for SR proteins-mediated gene regulation; what are …