Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 171 for “"RNA binding protein"”.
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Functional characterization of the RNA binding protein RALY
… from genome, more than 90% are subject to alternative splicing or other post-transcriptional modifications. All these events produce a high number of different proteins that form the basis for the high variety of cells. The RNAbinding proteins (RBPs) play crucial roles in this variability by …
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Post-transcriptional coordination by an RNA-binding protein
RNA-binding proteins can regulate the stability, localization, and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular processes in response to various stimuli. Filamentous growth in …
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Regulation and function of the RNA-binding protein CELF1
… of decay of networks of functionally related mRNA provides a cell the ability to quickly and precisely alter its transcriptome in response to environmental signals. An important regulator of mRNA decay is the RNA binding protein CUGBP1 and Etr3 Like Factor 1 (CELF1). CELF1 binds to a GU-rich …
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
… (embryonic lethal abnormal vision) family of RNA binding proteins, selectively binds to AREs (AU-rich elements) and mainly stabilizes ARE-containing mRNAs, e.g. TNFα, VEGF, c-FOS, favoring specific protein translation. TNFα mRNA is one of the most important target mRNA of HuR since the protein …
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THE RNA-BINDING PROTEIN LRP1 MEDIATES FLOWERING TIME IN ARABIDOPSIS
… autonomous pathway. We show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating <i>FLC</i> mRNA levels. <i>LRP1</i> mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. …
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The Role of the Rna‐Binding Protein Hur in Colorectal Carcinogenesis
… region (3'UTR) of tightly regulated mRNAs like COX-2 allow for highly controlled mRNA expression and help signal for rapid mRNA decay when the cell no longer requires it. This is facilitated through cellular RNA-binding proteins that function as mediators of mRNA decay, stability, or …
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
RNA-binding proteins (RBPs) are key components of the post-transcriptional regulatory framework and can determine the translational fate of their RNA targets. A wide variety of post-transcriptional regulatory mechanisms are employed during the early Drosophila embryo and it has been established as …
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
ZFP36L1 is an RNA-binding protein which functions as a mRNA decaying protein through binding to the adenylate-uridylate rich elements (AREs) located in the 3’ untranslated region (3’UTR) of mRNAs, thereby mediating mRNA decaying. ZFP36L1 has emerged as a breast cancer driver gene, exhibiting …
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The neuronal RNA binding protein HuB as a potential tumor suppressor in glioblastoma
… tumors, we correlated genomic alterations and mRNA levels of RNA-binding proteins (RBPs) in 372 publicly available GBM samples and identified 56 RBPs whose copy number alterations correlate with their altered expression levels in at least 15% of the samples. Among the genes identified using our …
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THE ROLE OF THE RNA-BINDING PROTEIN TRISTETRAPROLIN IN CERVICAL AND COLORECTAL CANCERS
<p> Messenger RNA decay is a critical mechanism to control the expression of many inflammation- and cancer-associated genes. These transcripts are targeted for rapid degradation through AU-rich element (ARE) motifs present in the mRNA 3' untranslated region (3'UTR). Tristetraprolin (TTP) is an …
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The role of the RNA-binding protein FUS in axonal organisation and disease
The role of the RNA-binding protein FUS in axonal organisation and disease In this thesis, I discuss the role of the RNA-binding protein Fused in sarcoma (FUS) in axonal organisation and disease. FUS aggregates in forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
The RNA binding protein (RBP) ZFP36L1, which binds to adenylate/uridylate (AU)-rich elements (AREs) (AU-RBP) in the 3’ untranslated region of many messenger RNAs, has been extensively characterised for its role in post-transcriptional control of gene expression and is reported as a newly identified …
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Characterization of a single TRAM domain RNA-binding protein from the Antarctic methanogen Methanococcoides burtonii
… temperatures below 4 degrees and nucleic acid binding proteins have been inferred to play important roles in cold adaptation. In this thesis, the three M. burtonii ctr (cold-responsive TRAM domain) genes (proteins) Mbur_0304, Mbur_0604 and Mbur_1445 are referred to as ctr1 (Ctr1), ctr2 (Ctr2) …
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The Paraneoplastic Antigen Nova-1 is a Neuron Specific and Sequence Specific RNA Binding Protein
<p>We have identified a cDNA encoding a protein that is recognized by sera from (7/7) patients with paraneoplastic opsoclonus-myoclonus ataxia (POMA). The gene, Nova-1, encodes a novel nuclear RNA binding protein (RBP) that is extremely highly conserved (99% amino acid identity) between human and …
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Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
… REQUEST.] Posttranscriptional gene regulation by RNA-binding proteins such as HuR fine tunes gene expression in T cells leading to powerful effects on immune responses. HuR can stabilize target mRNAs and/or promote translation by interacting with their 3-UTR AUrich elements. We discovered that the …
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Investigation of RNA-Binding Protein Expression Changes in the Hippocampus Following Doxorubicin and Cyclophosphamide Treatment
… of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) (21% decrease, p=0.0298), compromised astrocytic network integrity evidenced by reduced GFAP-positive area in cornu ammonis 3 (CA3) (24%, pB=0.026) and dentate gyrus (DG) (19%, pB=0.027) regions, and elevated cellular senescence …
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Microscopic characterization of a putative ER-membrane targeted Puf RNA-binding protein in Arabidopsis thaliana
Cellular messenger RNAs (mRNAs) are associated with RNA-binding proteins (RBPs) that form ribonucleoprotein (RNP) complexes. These RNP complexes are the functional units that participate in post-transcriptional gene regulation activities. One group of RBPs that plays an important role in regulating …
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Biophysical and Therapeutic Approaches to Neurodegenerative Disease: Insights From Lysosomal and RNA-Binding Protein Systems
… failures in the cellular systems that maintain protein and RNA homeostasis, yet how distinct molecular defects contribute to the disease pathogenesis is incompletely understood. This dissertation investigates two complementary arms of this network: lysosomal quality control mediated by …
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