Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 409 for “"RNA binding"”.
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RNA-binding proteins in yeast mitochondria
… 1 (Mdh1p) both of which have been identified as RNA-binding proteins without known RNA recognition motifs. Besides analysing their effects on mitochondrial translation and their organisation in protein complexes the work focused on the characterisation of the RNA-binding properties of recombinant …
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Identification and investigation of RNA-binding ligands
… dystrophy type 1 is caused by a toxic CUG RNA repeat expansion in the 3’-UTR of the DMPK gene that sequesters a key splicing regulator, MBNL1, preventing normal modulation of alternative splicing of a variety of genes. Targeting these repeats with small molecules could block the …
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Investigation of m6A-regulated RNA-binding proteins
… the most ubiquitous modifications of eukaryotic RNAs. The modifi- cation functions to control the normal processing, export, splicing, and metabolism of cellular RNAs. All of these processes are mediated by a group of m6A RNA-binding proteins known as ‘readers’ that bind modified RNA - directly …
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RNA binding proteins in neurotoxic protein clearance
… which we hope may provide leads for future work. RNA binding proteins stand out as enriched amongst genes that modify α-Syn levels in our screens – particularly core protein components of stress granules (SGs). SGs are autophagy substrates, and have received much attention as a result of newly …
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Functional characterization of the RNA binding protein RALY
… from genome, more than 90% are subject to alternative splicing or other post-transcriptional modifications. All these events produce a high number of different proteins that form the basis for the high variety of cells. The RNAbinding proteins (RBPs) play crucial roles in this variability by …
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Post-transcriptional coordination by an RNA-binding protein
RNA-binding proteins can regulate the stability, localization, and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular processes in response to various stimuli. Filamentous growth in …
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Understanding regulation of mRNA by RNA binding proteins
Posttranscriptional regulation of mRNA by RNA-binding proteins plays key roles in regulating the transcriptome over the course of development, between tissues and in disease states. The specific interactions between mRNA and protein are controlled by the proteins' inherent affinities for different …
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Regulation and function of the RNA-binding protein CELF1
… of decay of networks of functionally related mRNA provides a cell the ability to quickly and precisely alter its transcriptome in response to environmental signals. An important regulator of mRNA decay is the RNA binding protein CUGBP1 and Etr3 Like Factor 1 (CELF1). CELF1 binds to a GU-rich …
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Biochemical and functional characterization of human RNA binding proteins
RNA not only shuttles information between DNA and proteins but also carries out many other essential cellular functions. Nearly all steps of an RNA's life cycle are controlled by approximately one thousand RNA binding proteins (RBPs) that direct RNA splicing, cleavage and polyadenylation, …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… The-HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 expression is induced in diseased, but not normal arteries. SiRNA knock down of FXR1 increases abundance and stability of inflammatory mRNAs, while overexpression …
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
… (embryonic lethal abnormal vision) family of RNA binding proteins, selectively binds to AREs (AU-rich elements) and mainly stabilizes ARE-containing mRNAs, e.g. TNFα, VEGF, c-FOS, favoring specific protein translation. TNFα mRNA is one of the most important target mRNA of HuR since the protein …
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THE RNA-BINDING PROTEIN LRP1 MEDIATES FLOWERING TIME IN ARABIDOPSIS
… autonomous pathway. We show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating <i>FLC</i> mRNA levels. <i>LRP1</i> mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. …
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Mapping RNA Binding Surfaces on Hfq Using Tryptophan Fluorescence Quenching
… a pleiotropic posttranscriptional regulator and RNA chaperone that facilitates annealing of trans-encoded sRNA/mRNA pairs. It regulates many different cellular pathways including environmental stress responses, quorum sensing, virulence and maintenance of membrane integrity. Hfq is a member of …
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Single molecule pull down of double strand RNA binding proteins
RNA molecules are transcribed as single stranded naturally, but with most of them forming in to structures composed of duplex regions, loop, bulge or mismatches. RNAs with double stranded regions, or known as double-strand RNAs (dsRNAs). The class of proteins responsible for processing dsRNAs is …
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Probing RNA binding specificities of AID/APOBEC proteins by iCLIP
… modifying cytosine to uracil in the context of RNA or singlestranded DNA. They exert diverse valuable physiological functions including antibody diversification and restriction of viral infection. However, off-target mutations have also been shown to contribute to cancer development, making it …
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CHARACTERIZATION OF THE RNA BINDING MODE OF A PLATINUM-ACRIDINE AGENT
… its cytotoxic effect by two synergistic DNA binding mechanisms: monofunctional platination and intercalation of the acridine chromophore. The RNA binding of platinum drugs has been studied to a much lesser extent. Recently, the RNA interactions of platinum-containing drugs and drug conjugates …
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Regulation of Pumilio RNA Binding Proteins by Long Noncoding RNA NORAD
… and encodes thousands of long noncoding RNAs (lncRNAs). Defining the mechanism of action of lncRNAs has been a critical challenge and priority for understanding their biological functions. An important example of this is the lncRNA NORAD, which is a highly conserved lncRNA that is …
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Protein-dependent prediction of messenger RNA binding using Support Vector Machines
RNA-binding proteins interact specifically with RNA strands to regulate important cellular processes. Knowing the binding partners of a protein is a crucial issue in biology and it is essential to understand the protein function and its involvement in diseases. The identification of the …
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Computational analysis of cooperation and competition mechanisms between RNA-binding proteins
… regulatory trans-elements forming this network, RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of gene expression (PTR). Understanding RBPs behavior is therefore crucial given their participation in all stages of the mRNA life cycle. Although an increasing amount of …
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The Role of the Rna‐Binding Protein Hur in Colorectal Carcinogenesis
… region (3'UTR) of tightly regulated mRNAs like COX-2 allow for highly controlled mRNA expression and help signal for rapid mRNA decay when the cell no longer requires it. This is facilitated through cellular RNA-binding proteins that function as mediators of mRNA decay, stability, or …
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