Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"RNA Velocity"”.
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Dynast: Inclusive and efficient quantification of metabolically labeled transcripts in single cells
Single cell RNA velocity, defined as the time derivative of gene expression, is a powerful concept that can predict the future transcriptional state of the cell. Traditionally, RNA velocity estimations relied on the distinction between spliced and unspliced mRNA in single cell RNA-seq (scRNA-seq) …
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Single-cell differential splicing of Alzheimer’s Disease in 1.9 million cells across 416 individuals
… steady-state cell behavior. By contrast, RNA velocity analysis allows inference of both direction and magnitude of regulatory changes occuring over disease progression. However, despite the success of existing RNA velocity analyses, the pace of disease progression remains uncharacterized, …
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Probabilistic Dynamical Modelling of Spatiotemporal Cell Trajectories During Neural Development
… in health and disease. Cell2fate is an RNA velocity model for inference of transcriptional dynamics from spliced and unspliced RNA counts. Unlike existing models, cell2fate is capable of capturing complex biological processes while still being analytically tractable. This is achieved …
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Towards causality in gene regulatory network inference
… Granger causal framework that leverages RNA velocity dynamics for causal gene regulatory network inference and enables inquiries into the role of temporal control in gene regulatory function and disease.
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Biophysical dynamical priors in machine learning
… 5 extends the popular biological framework, RNA velocity, both to reduce invalid assumptions and to enable the inference of single-cell resolution quantities such as pseudotime. Finally, Chapter 6 presents a conclusion on all the work conducted along with directions for future work.
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Mechanistic modeling and systems analysis across biological scales, from single cells and regulatory networks to microbial communities
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Identification of viral and cellular factors that modulate heterogeneity in IFN induction during influenza infection
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Deciphering the Mechanisms of Heterogeneity within Haematopoiesis in Health, Development & Disease
… by single cell transcriptomic sequencing (scRNA-seq), combined with its interpretability, has been a pivotal driver to our understanding of haematopoietic heterogeneity and the mechanisms driving it. scRNA-seq focusses exclusively on measuring spliced mRNA transcript abundance within cells. …