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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 12 of 12 for “"RNA Transport"”.

  1. Messenger Ribonucleoprotein (Mrnp) Complexes: Proteomic and Functional Analysis

    Ling, Shuo-ChienUniversity of Illinois at Urbana-Champaign2015

    … identify the detailed molecular mechanisms for RNA transport, we developed an in vivo functional assay and went on to provide evidence that dFMRP and associated mRNAs are actively transported by molecular motors. We were able to not only identify the motors that are required for the movement of …

    uiuc Repository record

  2. Translocation of a Semiflexible Polymer Through a Nanopore

    Adhikari, Ramesh

    <p>The transport of a biomolecule through a nanopore occurs in many biological functions such as, DNA or RNA transport across nuclear pores and the translocation of proteins across the eukaryotic endoplasmic reticulum. In addition to the biological processes, it has potential applications in …

    ucf

  3. Lysosomes and Ribonucleoprotein Dynamics in Neurons

    Fernandopulle, MichaelUniversity of Cambridge2021

    … lysosomal surface. ANXA11 is also a component of RNA granules, and its bipartite domain organization allows it to act as a tether between RNA granules (N-terminal phase separation) and the lysosomal surface (C-terminal phospholipid binding). We find that ANXA11 enables RNA granule hitchhiking on …

    cambridge Repository record

  4. A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease

    Serganov, Artem

    … metabolism, protein synthesis, nuclear and RNA transport across the nuclear pore complex, apoptosis, and innate immune responses. Picornaviruses are the most dominant human disease-causing viruses and present an excellent clinical target for research studies into their molecular mechanisms. …

    rockefeller Repository record

  5. Understanding compound-induced histopathology in rat liver using gene expression network methods

    Alexander-Dann, BenjaminUniversity of Cambridge2019

    … This found underlying biological terms such as RNA transport, ribosome biogenesis and translation as well as toxicity-specific terms (aminoacyl t-RNA synthesis in metabolic processes for the histopathological observations of glycogen accumulation, cellular infiltrate, hepatocellular necrosis and …

    cambridge Repository record

  6. New Roles in RNA Stability and Transcription for the RNA Export Protein, REF/Aly

    Stubbs, Sarah Elizabeth Hulsey2016

    Pre-mRNA processing consists of a series of events including capping, splicing, and polyadenylation, which occur co-transcriptionally, are interdependent, and are coupled to other steps in gene expression including transcription and RNA export. For example, in mammalian cells the TREX …

    utswmed Repository record

  7. Computational analysis of regulatory networks using genome-scale data

    Joshi, Anagha MadhusudanGhent University. Faculty of Sciences2009

    … regulatory networks respond to the external environment, optimizing the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to alcohol. Central dogma of molecular biology …

    ghent Repository record

  8. Molecular aspects of RNA-recognition by the neuronal mRNA transport factor Staufen 2

    Heber, SimoneUniversität Ulm

    ulm-diss Repository record

  9. The role of the RNA-binding protein FUS in axonal organisation and disease

    van Tartwijk, FrancescaUniversity of Cambridge2022

    The role of the RNA-binding protein FUS in axonal organisation and disease In this thesis, I discuss the role of the RNA-binding protein Fused in sarcoma (FUS) in axonal organisation and disease. FUS aggregates in forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and …

    cambridge Repository record

  10. Biochemical and Structural Analysis of the Nucleoporin Nup214 and its Involvement in mRNA Export

    Napetschnig, Johanna

    … sense of the architecture and regulation of the mRNA export machinery at the NPC, I set out to biochemically and structurally characterize Nup214. In this thesis, I present the crystal structure of the human Nup214 N-terminal domain at 1.65 Å resolution. The structure reveals a sevenbladed …

    rockefeller Repository record

  11. Identification of hepatitis C virus core protein residues critical for the interaction with the cellular DEAD-Box Helicase DDX3 and their functional relevance

    Dalrymple, David A.University of Glasgow2007

    Hepatitis C virus (HCV) is a single-stranded RNA virus belonging to the Flaviviridae and infects approximately 170 million people worldwide. Unlike other known RNA viruses, HCV causes a persistent infection in the majority of infected people and can lead to cirrhosis of the liver and hepatocellular …

    glasgow Repository record

  12. Identifizierung neuer vegetal lokalisierter RNAs in der Xenopus laevis Oozyte und deren funktionelle Charakterisierung

    Horvay, Katja2012

    Am vegetalen Pol der Xenopus laevis lokalisierte mRNA Moleküle haben eine wichtige Funktion während der frühembryonalen Entwicklung. Mit dem Ziel, neue vegetal lokalisierte mRNA Moleküle zu isolieren, wurden 10000 cDNA Klone einer mit vegetal-kortikal lokalisierten Transkripten angereicherten cDNA …

    goettingen Repository record