Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"RNA Sequencing Single-cell"”.
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… in biomedical research, especially in single-cell omics (e.g. single-cell RNA sequencing, single-cell spatial profiling) have given us unprecedented power to decipher the intricate cellular and molecular features that maintain—or disrupt—this balance. However, validating the causality …
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Phenotypic dynamics of rectal cancer under neoadjuvant therapy: a multi-omic single-cell perspective from patient-derived organoids [Evoluzione fenotipica del carcinoma del retto durante terapia neoadiuvante: una prospettiva multi-omica a singola cellula da organoidi derivati dal paziente]
… — comprendente sequenziamento bulk, single-cell e in long-read — abbiamo tracciato l’evoluzione delle cellule tumorali sottoposte a pressione terapeutica. Questa strategia ha permesso di identificare programmi trascrizionali, stati fenotipici e isoforme di splicing che emergono …
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Using RNA sequencing to identify transcriptomic differences in the renal pelvis
… A specialized population of resident pacemaker cells are required to initiate and maintain peristalsis; however, the precise mechanisms that underlie pacemaker function remain undetermined. By studying gene expression of pacemaker cells, our goal is to gain further insight as to the workings of …
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Cross-species single-cell transcriptomics and its applications in evolutionary and translational research
Single-cell transcriptomics has emerged as a powerful technology to characterise gene expression within individual cells. Over the last 5 years, as the technology has matured, single-cell techniques have been used to profile cells in species across the tree of life. The availability of single-cell …
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Defining cell state regulators in cancers using single-cell analysis and CRISPR-Cas9 screening
… higher levels of plasticity. Development of single-cell profiling has had a particular impact for elucidating the composition of cell states occurring within individual tumours, and offers high-dimensional data which can be utilised for unsupervised signature extraction. The aim of this …
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Human Cellular Genetics of Innate Immunity
… to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between individuals, alongside cell-to-cell heterogeneity in a genetically identical cell population, the basis of this variation is not fully understood. In this PhD, …