Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"RNA Repeats"”.
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Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation
… complex, which consists of two large, non-coding RNA on the X transcripts (<i>roX1</i> and <i>roX2</i>) and five proteins. The roX RNAs have a critical role in complex localization to the X chromosome. Simultaneous mutation of <i>roX1</i> and <i>roX2</i> reduces X localization of the MSL proteins, …
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Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy
… The structure of the expanded DNA and RNA repeats that cause myotonic dystrophy type 1 (DM1) present a unique opportunity to develop sequence-selective small molecule inhibitors that bind to the DNA or RNA and inhibit RNA synthesis or aberrant RNA-protein interactions directly as well …
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Developing potential drugs for the treatment of myotonic dystrophy: from rational design to lead development
… Nevertheless, it is known that the alternative splicing regulator, MBNL1, is sequestered by two types of abnormally long RNAs. Specifically there are the tri- and tetra-nucleotide repeats, CUG and CCUG, in DM1 and DM2, respectively. This key discovery inspired the development of ligands …