Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"RNA Processing"”.
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Diverse RNA processing pathways important for post-transcriptional gene regulation
… elements in 3' untranslated regions (UTRs) of mRNAs are crucial to the regulation of gene expression. Animal microRNAs (miRNAs) each target hundreds of mRNAs, which are recognized by pairing to nucleotides 2-7 of the miRNA. MicroRNAs mature through sequential RNase III cleavage of characteristic …
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Identification of novel branch points reveals insights into RNA processing
Pre-mRNA splicing is a ubiquitous process necessary for the production of functional eukaryotic mRNAs. The branch point (BP) sequence is one of three key nucleotide sequences required for pre-mRNA splicing, however, in metazoa it has been less comprehensively studied than the 5' splice site (5'SS) …
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Computational Identification of Noncoding Driver Mutations Based On Impact On Rna Processing
… between noncoding mutations and functional RNA motifs. The goals for this study, therefore, were to identify RNA motifs that were significantly associated with the presence of somatic, noncoding mutations and to predict the functional impact of noncoding variants. The analysis was conducted …
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Functions of The Trna Splicing Endonuclease and Other Adventures In Rna Processing
<p>The tRNA splicing endonuclease (TSEN), has been studied for over three decades for its function in tRNA splicing. However, this enzyme has other functions that are just beginning to be characterized. Mutations in TSEN cause the neuronal disease pontocerebellar hypoplasia (PCH) that is …
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The functions of the RNA polymerase II CTD in transcription and RNA processing
RNA polymerase II (RNAP II), transcribing messenger RNAs (mRNAs), small nuclear RNAs (snRNAs), and non-coding RNAs (ncRNAs), is composed of 12 subunits. Rpb1, the largest subunit with catalytic polymerase activity, possesses a unique c-terminal domain (CTD) that consists of tandem heptad repeats …
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A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
… nuclear organization and proposed to regulate mRNA splicing. Mutations in MECP2 are linked to the severe postnatal neurodevelopmental disorder Rett Syndrome (RTT). To further understand MeCP2 and potential roles in RTT pathogenesis, we have employed a biochemical approach to identify the MeCP2 …
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Environmental sensing and response of conserved RNA-processing machines to specific external chemical cues
… time frame to provoke a physiological response. RNA-processing molecular machines are important players in the physiological response to environmental stress; however, relatively little is known about the specificity of their RNA substrate recognition and/or the ability for other chemical …
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Bop1 is a novel mouse nucleolar protein involved in ribosomal RNA processing and cell cycle progression.
… mouse nucleolar protein involved in ribosomal RNA processing and cell cycle progression.
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Novel Functions for Neuronal RNA Processing Bodies in the Control of Axon Terminal Growth in Drosophila Melanogaster
… functions for HPat/Pat1, a core component of RNA processing bodies or "P bodies". We show that <em>hpat</em> mutants exhibit a strong synaptic hyperplasia at the developing and acutely stimulated <em>Drosophila</em> larval neuromuscular junctions (NMJs). The synaptic defects observed in hpat …
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Role of RNA Processing Factors in the Expression of Flt-1 and its Secreted Variant, sFlt-1
… in vitro and in vivo. sFlt-1 is generated by alternative pre-mRNA processing; removal of Flt-1 intron 13 by splicing produces the mRNA for transmembrane Flt-1, whereas cleavage/polyadenylation within this intron, preserving the exon 13/intron 13 junction, yields sFlt-1 mRNA. Despite the likely …
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Gene Expression in Archaea: Studies of Transcriptional Promoters, Messenger RNA Processing, and Five Prime Untranslated Regions in Methanocaldococcus Jannashchii
… are involved in gene expression---transcription, RNA processing, and translation. To expand our knowledge of these processes in Archaea, I have studied transcriptional promoters, messenger RNA processing, and 5'-untranslated regions in Methanocaldococcus (Methanococcus) jannaschii. The promoters …
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An Investigation into the Effects of Alterations in Ribosomal Proteins S4 and S5 on Translational Accuracy, Ribosomal RNA Processing, and Ribosome Assembly
… indirectly by affecting amino acid pools or tRNA modification.
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A molecular analysis of the relation between TDP-43 and tau pathology
… is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor Protein (APP) generates P- amyloid (Ap) peptides which are deposited as amyloid plaques in AD brain. APP transcripts containing …
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Genome-Wide Human-Specific RNA Regulatory Elements in the Brain
… to organism complexity in eukaryotes. RNA regulation is strictly controlled by RNA-binding proteins that are important for the coordination and regulation of gene expression and eukaryotic cells have evolved intricate posttranscriptional mechanisms that permit for precise spatial and …
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Analysis of tandemly and divergently oriented spinach chloroplast promoters
… in higher plants frequently synthesize multiple RNA transcripts. Part of this heterogeneity in RNA is due to posttranscriptional RNA processing events; however, some chloroplast genes such as the $\beta$ subunit of the ATP synthase (atpB) may contain multiple promoters. Ba131 deletion analyses …
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Transcriptional response of O⁶-methylguanine methyltransferase deficient yeast to methyl-N-nitro-N-nitrosoguanidine (MNNG)
… factors and subsequently, induction of RNA processing (35% of genes incrementally induced) and kinases involved in protein phosphorylation. In the WT, the response was restricted to a transient repression of fundamental biochemical processes. Interestingly, a gene whose repression is …
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Analysis of Interrelationships Among NAD+, PARP1, ADP-Ribosylation, and Splicing in Murine Embryonic Stem Cells
… in epigenetic modifications, gene expression, RNA processing, and cellular metabolism. Previous studies have implicated poly(ADP-ribose) polymerase 1 (PARP1), an abundant nuclear enzyme that plays key roles in a variety of nuclear processes, in ESC self-renewal and lineage commitment. Given the …
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The Role of The Arched Helicases In Exosome-Mediated Function
<p>RNA processing and degradation are two important functions that control gene expression and promote RNA fidelity in the cell. A major ribonuclease complex, called the exosome, is involved in both of these processes. The exosome is composed of ten essential proteins with only one catalytically …
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Alternative expression forms of the bovine αₛ₁-casein gene
… the deletion is caused by exon 4 skipping during RNA processing and that a T→A transversion mutation at position +6 in the intron 4 splice donor site is responsible for this skipping (Mohr et al. 1994). The current investigation initially focused on the genetic aetiology of variant A animals in an …
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