Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"RNA Polymerase III"”.
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In vivo studies of repressors of RNA polymerase III transcription
RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of genes, including 5S rRNA and tRNAs. Pol III transcription has been shown to be upregulated in transformed and cancer cells, suggesting an important role in cell growth and proliferation. Its tight …
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Extra-Transcriptional Effects of Chromatin Bound RNA Polymerase III Transcription Complexes
Transcription by RNA polymerase III (Pol III) requires sequential assembly of Pol III-specific transcription factors. At the tRNA gene, the TFIIIC complex recognizes and specifically binds at intragenic promoter elements A-box and B-box and aids the assembly of TFIIIB to upstream of the …
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The regulation of RNA polymerase III transcription by protein kinase CK2
… depends primarily on the rate of translation. RNA polymerase (pol) III plays a key role in protein synthesis by catalysing the production of small, untranslated RNA molecules such as transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Indeed, recent evidence suggests that tRNAiMet production is …
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Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins
RNA polymerase III (pol III) is responsible for transcribing a set of genes that are involved in protein synthesis, including transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Pol III transcription levels are increased in many cancers, as increased protein synthesis is required for tumour growth. …
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STRUCTURAL INSIGHTS INTO RNA POLYMERASE III PRE-INITIATION COMPLEX AND THE PIONEER ROLE OF OCT1
Despite the central role of small non-coding RNAs in RNA metabolism and gene regulation, the mechanisms by which RNA polymerase III (Pol III) is selectively recruited to snRNA promoters remain poorly understood. This is particularly notable because Pol II- and Pol III-transcribed snRNA promoters …
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Isolation and characterization of an RNA polymerase III encoded gene of Pinus radiata and its use in pine transformation
… and genes for the second largest subunit of RNA polymerase II, gene T13794 and actin-2 of A. thaliana. Sequence heterogeneity, cell-specific expression and low transcript abundance are possible reasons for not being able to detect pine orthologs of these candidate genes in expression screens.
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Studies Towards a Total a Synthesis of Tagetitoxin
… pv. tagetis. It is a selective inhibitor of RNA polymerase III in eukaryotic cells and RNA polymerase in bacteria. Since its initial isolation and partial characterization, more than thirty years have passed without a fully characterized structure for tagetitoxin. While much research has been …
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Regulation of mammalian SINE transcription
… RT-PCR analysis showed no increase in B1 and B2 RNA levels in MeCP2 null mice kidneys. ChIP analysis of Dnmt1n/n p53-/- embryonic fibroblasts, which have less than 5% of the normal DNA methylation level, showed significant reduction in MeCP2 and MBD2 binding, confirming that their presence is DNA …
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Genetic and mechanistic analysis of heterochromatin spreading in the yeast S.cerevisiae
RNA Polymerase III transcribed tRNA genes are implicated in a wide variety of chromosome organizational functions that includes the ability to act as a boundary to heterochromatic silencing. A tRNA gene has been shown to be a major component of the barrier that prevents spreading of silencing from …
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Mechanismus des pre-tRNA-Spleißens : Struktur und Funktion pflanzlicher und animaler RNA-Ligasen
Transfer Ribonukleinsäuren werden von der RNA Polymerase III als Vorläufer tRNA transkribiert und durchlaufen eine Vielzahl von Reifungsschritten hin zur maturen tRNA. Neben der Hydrolyse der 5´- und 3´-Flanke durch die RNase P und die tRNase Z, sowie einer Vielzahl von Basenmodifizierungen, wird …
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The physiological consequences of loss of tRNA thiolation in Saccharomyces cerevisiae
… modifier, functions as a sulfur carrier in tRNA thiolation reactions. Urml is required for formation of the s2 moiety that is found as part of the more complex mcm5 s2 U34 modification on the anticodon wobble uridines of tGliUUC, of tGgluUUG and tLysUUU tRNAs in a variety of organisms. It has …
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The Modulation of Innate Immunity by Cellular and Viral Noncoding RNAs
… that endogenous and viral non-coding RNAs possess the ability to alter innate immunity and inflammatory responses. For example, endogenous non-coding RNAs can be recognized by pattern recognition receptors to trigger innate immune activation and inflammation. Many positive sense RNA …
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Mechanisms of transcription and translation dysfunction in disease: a novel FMRP-translation axis in Alzheimer’s and expansion of Pol III transcription in cancer
… across multiple layers, from chromatin state to RNA processing and translation. Crucially, a gene encodes an RNA molecule before it ever becomes a protein, and RNAs themselves are diverse in form and function. Dysregulation of RNA pathways is implicated in many diseases, like cancer, neurological …
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Human La Function in Expression of Coding Transcripts
… to as Sjogrens Syndrome antigen B (SSB), is an RNA-binding phosphoprotein first identified as an auto-antigen in patients suffering from Sjogrens syndrome and systemic lupus erythematosus. La proteins are present and indispensable in nearly all eukaryotes and exhibit conserved functions in RNA …
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Purification and characterization of TFIIIA from Acanthamoeba castellanii
… interest has been in studying the mechanisms of RNA polymerase III (Pol III) transcription and the regulation of this process in A. castellanii, which was specifically focused on TFIIIA. This factor only activates Pol Ill-mediated transcription from 5S RNA genes and is the first of three general …
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Novel RNA Targets of the Spinal Muscular Atrophy Protein
… and the spliceosome which catalyzes pre-mRNA splicing. The biogenesis of RNPs often involves complex and elaborate pathways involving post-translational modifications, transit into specific cellular domains, and several auxiliary factors including assembly chaperones. One of the …
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Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs
… a protein that binds with high specificity to tRNA genes (tDNA) and other polymerase III (Pol III) transcripts including several types of transposable elements (TEs). Primate-specific paralogs ZSCAN5A and ZSCAN5D also bind tDNAs, although ZSCAN5D preferentially recognizes a subset of TE-derived …
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Das Protein La/SS-B: Vom Autoantigen zur Zielstruktur für die Immuntherapie
… Prozessierung und nukleären Retention von RNA-Polymerase III-Transkripten wahr. Unter normalen zellulären Bedingungen ist das La-Protein außerdem in der Lage, zwischen Zellkern und Zytoplasma zu pendeln. Bei Zellstress, der nach UV-Exposition oder während einer viralen Infektion entsteht, …