Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"RNA, Viral"”.
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
… potential future spillovers and for other (+)ssRNA viruses that still lack approved pharmacological treatments such as Flaviviruses. Small molecule development stands out as the most promising approach, as it enables possibly oral administration, stockpiling, combinatorial therapy. (+)ssRNA …
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Novel acyclic nucleotide phosphonates against RNA viruses
… have been used for years as successful anti-viral agents against diseases such as HIV/AIDS and hepatitis while the drug ribavirin is one of the only drugs available for the treatment of RNA-viral infections which mainly affect the developing world. The large and unmet need for anti-RNA viral …
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An Investigation of the SHIV reservoirs in the lymphoid organs of HIV-vaccinated rhesus monkeys after SHIV challenge
… HIV epidemic. This study aimed to investigate viral reservoirs in the blood and lymphoid tissues after HIV vaccination and virus challenge using the rhesus macaque model. In addition, the study investigated the envelope sequences of the virus located in the potential reservoir sites in an …
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Genetische Assoziationsstudien der immunologisch relevanten Gene CCR5, CX3CR1 und RANTES zur klinischen Risikostratifizierung von Patienten mit chronischer Hepatitis C
… is influenced by a variety of epidemological and viral factors, as well as genetical traits of the host. This study examined the influence and impact of genetical variations of chemokine receptors such as CCR 5 and CX3CR1 and the chemokine RANTES on chronic hepatitis C. The polymorphisms of the …
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Sleep Homeodynamics And Wellbeing In Asymptomatic Hiv-Seropositive African American Women
… included CD4<sup>+</sup> cell count, HIV RNA viral load, wrist actigraphy, Pittsburgh Sleep Quality Index, Subjective Sleep Quality Questionnaire, Epworth Sleepiness Scale, Stanford Sleepiness Scale, plasma IL–6, Quality of Life Index, and Quality of Life Visual Analogue Scale.</p> …
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Clinical, pharmacokinetic, and genetic determinants of change in serum creatinine among Southern Africans on dolutegravir based antiretroviral therapy
… cohort starting dolutegravir-based antiretroviral therapy. Methods: We conducted a secondary analysis of data from participants in a randomised controlled trial of dolutegravir with tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide fumarate (TAF) plus emtricitabine (ADVANCE, …
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Electron microscopic studies on barley yellow dwarf virus infection in oats
… The virus is transmitted by aphids that inject viral particles into the phloem of the host during the feeding process. BYDVs remain restricted to the phloem tissue and cause cytopathological alterations that ultimately lead to complete obliteration of the infected cell. Phloem cells are …
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The role of RNA structures in the evolution of respiratory RNA virus genomes.
RNA secondary structures in RNA viral genomes play important roles in a range of functions, including packaging, protection from cellular nucleases, and regulating viral replication. Furthermore, RNA structures have been shown to be immunostimulatory. In the case of Influenza A virus (IAV), during …
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Engineering resistance to maize lethal necrosis
… resistant maize lines using an artificial microRNA (amiRNA) approach. MLN is a synergistic viral disease caused by the interaction of Maize chlorotic mottle virus (MCMV) with any maize-infecting member of the potyviridae. I used next-generation RNA sequencing to characterise the MLN outbreak in …
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Identificación y estudio de las interacciones virus-célula del vesivirus de conejo (RaV)
Los calicivirus son virus RNA de cadena sencilla y polaridad positiva que actúan como agentes patógenos en animales y humanos. El rango de huésped y el tropismo celular, así como el desarrollo de la infección, dependen en gran medida de la interacción con proteínas del huésped. En la presente …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
… genetic variants resistant to the host cell antiviral response and interferon (IFN)-based therapy. The development of the HCV RNA replicon system has allowed the study of persistent HCV RNA replication in tissue culture. We evaluated HCV/IFN interactions within a long-term culture system of Huh7 …
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Structural Basis for the Activation of RIG-I/MAVS Antiviral Immune Signaling
The file named "XU-DISSERTATION-2015.pdf" is the primary dissertation file. The supplemental file named "Movie 1.mp4" may be viewed individually.
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The Art of Viral Oncogenesis: Lessons from Human Papillomavirus and Polyomavirus Transformed Cancers
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses
… AEV nonproducer cells were found to contain two viral related RNA species of 28 S and 21 S. Both RNA species contain the AEV unique sequences and the "strong stop" region of the viral genome, as detected by cDNA hybridizatin. In addition to the 28 S RNA, which is the genomic RNA of AEV, the 21 S …