Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"RM Therapeutics. Pharmacology"”.
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PULMONARY DELIVERY OF RESVERATROL-LOADED NANOCOMPOSITE MICROPARTICLES TO TREAT LUNG CANCER
… loaded polymeric nanoparticles (NPs) formulated into nanocomposite microparticles (NCMPs) using L-leucine and chitosan were developed for the pulmonary delivery via dry powder inhalation. Resveratrol was loaded into NPs of poly(glycerol adipate-co-ω-pentadecalactone) (PGA-co-PDL) with …
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Development of New Synthetic Approaches to Biologically-Active Peptides
… which can be used for the development of new pharmaceuticals, there is also an increasing interest in rationally designed synthesised and optimised peptides. In the field of chemical biology peptides are used to understand complex biological processes, where gaining knowledge and understanding …
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
The epidermis is vitally important in protecting the organism from environmental insults. Consisting of dynamic outer strata of keratinocytes that terminally differentiate from basal keratinocytes stem cells (KSC), the epidermis is maintained by constant spatial and temporal control. In psoriasis, …
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MicroRNA Nanocarriers for the Treatment of Chronic Obstructive Pulmonary Disease
… However, none of the available pharmacological or non-pharmacological treatments for COPD have been shown to delay or correct long-term defects in lung function. Small nucleic acids such as non-coding RNA (ncRNA) and interference microRNA (miRNA) have recently gained attention as a …
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The Development of a Fragment-Based in silico Profiler for the Prediction of Thiol Reactivity and Toxicity
… etc.), in chemico (chemical experiments e.g. determination of reactivity) and in silico (computational) approaches. Importantly, it is envisaged that data from all these alternative sources will be required for the prediction of the animal-based endpoints used in regulatory toxicology. One of the …
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The Development of Analytical Procedures for Analysis of Trace Metals in Pharmaceutical Formulations and the Speciation of Arsenic in Antacids
… data obtained from the existing United States Pharmacopeia (USP) method, USP <231> for elemental impurities (EI) have been questioned in the literature. New regulations regarding EI in pharmaceutical products were recently implemented on the 1st January 2018. The new regulations are USP …
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Endophytic fungi of Cassia fistula L.
… species rarely produce their anamorphic form in culture and virtually no members of the Xylariaceae develop their teleomorph in culture. Therefore molecular techniques were used to compare DNA sequences of the ITS region from a selection of endophyes with sequences obtained from …
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Expression and characterisation of metalloproteins from mycobacterium tuberculosis
… expression trials of 36 unique targets were performed. Initial screening resulted in soluble expression for 30 % of the targets and inclusion of additives, such as molecular chaperones or detergents, increased this to 67 %. Milligram quantities of protein were obtained for eleven targets. As a …
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Drug release from pellets and matrices based on cellulose ethers.
… transitions of the polymeric films were determined by thermomechanical analysis and used as a guideline to select the inlet air temperature m coating operation. The coating procedure was performed using Accela-Cota. Matrices were prepared either by direct compression or wet granulation. …
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Performance and characteristics of controlled release matrices composed of hydroxpropylmethylcellulose and other polymers.
… dissolution methodology was used to determine drug release from matrices and their release exponents. Propranolol hydrochloride increased the solubility of HPMC and altered the water distribution in their gels. The release of propranolol hydrochloride from HPMC matrices was dependent on …
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The effect of speed of compression on the properties of compacts.
… was found to consolidate mainly by plastic deformation with a lesser contribution from the melting of asperities. A significant amount of pressure induced melting and subsequent fusion bonding occurred at higher pressures. Ibuprofen was found to be sensitive to the magnitude and rate of …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… A (PspA). A potential dry powder vaccine formulation containing polymeric nanoparticles (NPs) adsorbed with PspA4Pro and formulated into nanocomposite microparticles (NCMPs) using L-leucine (L-leu) to be delivered via inhalation was developed. Poly(glycerol adipate-co-ω-pentadecalactone), …
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A nutritional evaluation and optimisation of infant foods using microencapsulation
… Children. The current nutritional labelling formats for ready-to-eat complementary infant foods are a duplicate of the legislative requirements for manufacturing of ready meals, intended for the general population, the implication of this is that a number of important nutrients maybe limiting …
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Enabling carers to administer depot injections: an action research study
… medication. An action research study informed by empowerment theoretical perspectives and influenced by recovery philosophies was used to explore the issues about ‘supportive person’ depot administration. Methods used to collect data included case studies, interviews, observation, …
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Analysis of the effects of three commercially available supplements on performance, exercise induced changes and bio-markers in recreationally trained young males
Commercially available multi-ingredient formulas are ingested by the recreationally trained population to optimise training outcomes; however, there remains no convincing evidence in regards to their effectiveness. Thus, the aim of this project was to analyse the effects of three different …
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Studies on acute hyperbaric pulmonary oxygen toxicity
Abstract available: p.17-18
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Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons
… in mammals exists in two inter-convertible forms: xanthine dehydrogenase (XDH) (the predominant intracellular form under physiological conditions) and xanthine oxidase (XO). A combination of XO and its oxidizable substrate xanthine (X) (or hypoxanthine (HX)) is widely used as a model to …
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Regulation and desensitisation studies on the nicotinic acid receptors
… between these receptors is the longer C-terminal tail of HM74. As the C-terminal tail of GPCRs is often implicated in receptor regulation it was hypothesised that the differences in this region may result in differential regulation of HM74 and HM74A. This hypothesis was tested by examining …
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