Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"RLRs"”.
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Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
<p>Upon viral infections, RIG-I-like receptors (RLRs) sense cytosolic viral RNAs and initiate signaling pathways culminating in the activation of IRF3 and subsequent type I interferon (IFN) antiviral response. This intrinsic protective mechanism is orchestrated by a host of positive and negative …
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… family (PRRs). Among PRRs, RIG-I-like receptors (RLRs), including RIG-I, MDA5 and LGP2, are responsible for sensing intracellular viral RNAs. MAVS, a mitochondria-localized transmembrane protein, transduces signaling from RIG-I and MDA5 to activate downstream transcription factors IRF3 and NF-kB, …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
The RIG-I-like receptors (RLRs), RIG-I and MDA5, are innate sensors of RNA virus infections that are critical for mounting a robust immune response. RIG-I and MDA5 both signal to MAVS to induce antiviral cytokine induction but respond to different viruses and are activated by distinct mechanisms. …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… double knockout mice and found that lack of both RLRs results in a complete absence of innate immune gene induction in target cells of WNV infection and a severe pathogenesis during infection in vivo, similar to animals lacking MAVS, the central adaptor molecule for RLR signaling. We also found …
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
… oligomerisation in cells. RIG-I-like receptors (RLRs), RIG-I, MDA5 and LGP2 sense cytosolic viral dsRNA and then promote oligomerisation of the mitochondrial antiviral- signalling protein (MAVS) on the outer mitochondrial membrane. MAVS signalling induces activation of cytosolic kinases, which in …
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Management of Neurotrauma in Low-Resource Settings
… with sTBI in regions of limited resources (RLRs). Limitations of care for sTBI include suboptimal or non-existent prehospital care, overburdened emergency services, lack of trained human resources, and surgical and intensive care. Low-cost neuromonitoring systems are currently in testing, …