Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"RLR"”.
-
LONG-TERM EFFECTS OF CONFIRMATION LIGHTS AND FACTORS THAT LEAD TO RED LIGHT RUNNING
Red Light Running (RLR) is a safety concern for communities nationwide. The Federal Highway Administration (FHWA) reported a total of 676 fatalities in 2009 were due to RLR. The Insurance Institute for Highway Safety (IIHS) reported that more than half of RLR crash fatalities are other than the …
-
Evaluation of the Effectiveness of Blank-Out Overhead Dynamic Advance Warning Signal Systems
… to reduce the frequency of red-light running (RLR) and crashes. A new advance warning signal design was tested on an approach to an HSSI in Utah to study the effects of the modified design on motorist behavior. The new design utilized an overhead dynamic blank-out sign and flashers. A …
-
Relationship of plankton and marine snow to hydrography and currents on the south portion of Georges Bank during June 1997
… corner of the bank, the retention-loss region (RLR). Analysis of field data (Video Plankton Recorder, Acoustic Doppler Current Profiler, and satellite-tracked drifters) and modeling results was performed to quantify the relationships between plankton, hydrography, and currents and the fluxes …
-
Relationship of plankton and marine snow to hydrography and currents on the southwest portion of Georges Bank during June 1997
… corner of the bank, the retention-loss region (RLR). Analysis of field data (Video Plankton Recorder, Acoustic Doppler Current Profiler, and satellite-tracked drifters) and modeling results was performed to quantify the relationships between plankton, hydrography, and currents and the fluxes …
-
The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… receptors: TLR) and the Rig-I-like receptors: RLR). Among the TLRs, TLR3 binds dsRNA within the endosomal compartment and initiates signaling through its downstream adapter TRIF. Melanoma differentiation-induced gene 5: MDA5) is a member of the RLR family that recognizes dsRNA within the …
-
Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the adaptors TRIF (TLR3, 4), MyD88 (TLR4, 7/8, 9), and MAVS (RIG-I). The innate response serves to limit viral spread and to activate adaptive immune …
-
Characterization of Ebola virus VP35-dsRNA binding for drug development against Ebola virus disease.
… VP35 interaction with the RIG-I like receptors (RLR) cascade components inhibits the interferon (IFN) production, impeding proper host immune response. Hence, it has been shown that VP35 is a validate drug target. Full-length His-tagged recombinant VP35 (rVP35) has been previously expressed in …
-
The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… receptors (PRRs) of the RIG-I-like receptor (RLR) protein family that recognize viral RNA and activate defense programs that suppress infection. We evaluated the individual functions of RIG-I and MDA5 both in vitro and in vivo in pathogen recognition and control of WNV. Lack of RIG-I or MDA5 …
-
Computational and experimental analysis of the effects of manufacturing tolerances on the performance of a regenerative liquid ring pump
The regenerative liquid ring (RLR) pump is a type of rotodynamic pump which combines the mechanical impulses of the impeller with centrifugal force. The head is increased through recirculation, or regeneration, of the fluid in the impeller blades. The design of the regenerative machine has evolved …
-
Interpreting American Indian Cultural Heritage: Visitor's Educational Experience at Rock Ledge Ranch Historic Site
… if and how the interpretational techniques at RLR influence visitor's educational experience, further the discourse of American Indian cultural heritage, and broaden the perspectives and knowledge of its visitors regarding American Indian cultural heritage.</p>
-
lncRNA RPPH1 in melanoma: novel functions as cargo of tumor-derived Extracellular Vesicles
… RPPH1 cargo, activate the RIG-I-like receptor (RLR) pathway in recipient macrophages, triggering an inflammatory response characterized by the upregulation of interferon-stimulated genes (ISGs) and pro-inflammatory cytokines. Single-cell RNA sequencing revealed that this EV-mediated signalling …
-
Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
<p>Upon viral infections, RIG-I-like receptors (RLRs) sense cytosolic viral RNAs and initiate signaling pathways culminating in the activation of IRF3 and subsequent type I interferon (IFN) antiviral response. This intrinsic protective mechanism is orchestrated by a host of positive and negative …
-
Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis
The innate immune response plays a crucial role in recognising and combating viral infections. Double-stranded RNA (dsRNA) is a potent proinflammatory signal, and its recognition by MDA5 and its coregulatory factor, LGP2, is essential for initiating antiviral responses. This study aimed to …
-
Innate sensing and regulation during enteric caliciviruses infections
Several decades after the discovery of the human norovirus, with thousands of lives and billions of dollars lost, the lack of a robust cell culture system still severely hampers development of vaccines and therapeutics. This is likely in large part as a result of our limited understanding of the …