Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"RL Dermatology"”.
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Development of inducible transgenic mouse models for melanoma
… lack of melanoma phenotype in vivo particularly in addition of PTEN loss, this culture protocol supplied a successful test of oncogenic potential of N-Raslys61 and PTEN loss in vitro, where N-Raslys61 expression transformed melanocytes and PTEN loss promoted N-Raslys61 to give more aggressive …
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The rational design of dermatological formulations
In order to understand the role of the formulation components in topical drug delivery it is necessary to separate the various contributing factors, these include thermodynamic activity effects, changes in the ionisation state of the permeant and alteration of the membrane properties. Three model …
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Regulation of apoptosis and desmosomes by RhoE
… group of signaling proteins that have been clearly implicated in epidermal function are the Rho family of small GTP-binding proteins. This thesis focuses on one member of the family, RhoE/Rnd3, and the analysis of the role it plays in the regulation of proliferation, differentiation, apoptosis …
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Lymph node metastasis in auricular squamous cell carcinoma
… examines the use of this technique to identify early tumour spread and a retrospective analysis of cases of auricular squamous cell carcinoma in our unit examines histopathological prognostic indictors of metastatic spread. Results The systematic review found that these tumours have a metastatic …
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Interaction between Leishmania parasites and mammalian macrophages
… studies have been undertaken to understand early stages of the parasite interaction with macrophages; however, few have investigated the later stages of infection. This study was undertaken to develop an experimental model to examine the fate of the parasites when they leave the safe …
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Presence and Role of Acanthamoeba in Wound Infections
Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa are the main multi-drug resistant pathogens associated with deep wound infections which then may cause septicaemia. Treatment is problematic and re-infection is quite common. Free Living Amoebae (FLA), such as …
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Development of an analytical method to derive hydrophobicity parameters for use as descriptors for the prediction of the environmental and human health risk of chemicals
There is a requirement to assess the safety of chemicals to both 'man' and the environment. Traditionally this was determined through the use of animal testing. However, there is an increased need to develop alternatives to animal testing for the determination of toxicity due to ethical and …