Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"RJ Pediatrics"”.
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Nutritional aspects and gut microbiota in paediatric inflammatory bowel disease
As Crohn’s disease (CD) is a disease of the gastrointestinal tract, nutrition is very important and is implicated in several aspects of the disease, from aetiology, management, and the long-term health of the patient. Nutritional therapy with EEN is the mainstream approach in the management of …
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Molecular genetic investigation of autosomal recessive neurodevelopmental disorders
Development of the human brain occurs in a number of complex pre- and postnatal stages which are governed by both genetic and environmental factors. Aberrant brain development due to inherited defects may result in a wide spectrum of neurological disorders which are commonly encountered in the …
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Aminoaciduria in childhood
Paper partition chromatography has been used extensively to study the aminoacid excretion in the urine of healthy children, of newborn infants and of patients suffering from eight different metabolic disorders. The purpose of this investigation was to discover the aminoacid pattern in the urine and …
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Study to evaluate paediatric Accident and Emergency services within England and Wales
This Study aimed to describe paediatric Accident and Emergency (A&E) care within England and Wales, identify barriers to providing a service which complies with guidelines and to recommend action to improve child centred A&E care within the West Midland’s A&E departments. A questionnaire built upon …
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The development and evaluation of a scale to assess pain in the post-operative neonate.
Debate surrounding the issue of pain management in neonates has mushroomed over the last ten years. Previously held beliefs that neonates do not feel pain because their anatomical make up is different from that of an adult, and that they do not remember pain therefore there is no need to relieve it …
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Three-dimensional assessment of dentofacial deformity in children with clefts
Background: Changes in clinical management; advances in non-invasive three-dimensional imaging; developments in methods of shape analysis. Aim: To assess three-dimensional dentofacial deformity with a view to early appraisal of primary surgical outcome. Results: Significant differences in upper lip …
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Three-dimensional assessment of facial morphology in infants with cleft lip and palate
Differential growth was demonstrated between facial features and within some facial features. In particular, the columella, nostrils and philtrum did not grow significantly after surgery, although this would be considered normal in the age group studied. Facial growth in children with UCL and UCLP …
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Staged surgical palliation and ventricular performance in functionally single ventricle anatomy
This thesis reports a series of laboratory and clinical studies designed to investigate the acute effect of surgical palliation on ventricular function in children with functionally single ventricle anatomy. Ventricular volume and pressure were measured using a combined pressure-conductance …
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THE EFFECT OF PHYSICAL GROWTH, BIOLOGICAL MATURATION AND ETHNICITY ON CARDIAC PRE-PARTICIPATION SCREENING IN MALE PAEDIATRIC ATHLETES
Cardiac screening of the paediatric athlete is now recommended by many international sporting governing bodies and aims to identify those at risk of sudden cardiac death/arrest (SCD/A) from an undiagnosed cardiac condition. Regular and sustained physical activity is associated with a number of …
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Muscle responses to stretching and developing effective interventions in children with cerebral palsy
Hyper-resistance at the joint is one of the most common symptoms in children with cerebral palsy (CP). There are both neural and non-neural factors contributing to the observed joint hyper-resistance. Non-neural alterations to the musculoskeletal system such as a reduced muscle length, increased …
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Human brain lipid fatty acid composition in relation to infant diet
Brain tissue, both grey and white matter from the cerebral parietal region and the cerebellum, was obtained from 66 infants dying of sudden infant death syndrome. The fatty acid composition was analysed in these tissues by gas liquid chromatography after extraction and derivatisation. The subjects …
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Does combining physiotherapy with Botulinum toxin type A injections improve the management of children with spastic cerebral palsy?
Cerebral palsy (CP) affects around every one in 500 children born. It isn’t a particular illness or disease, but an umbrella term used to describe a physical condition that affects movement as a result of injury to the brain. There are several types of CP, the main ones being spastic, athetoid and …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
Since the introduction of glucocorticoids (GCs) in the treatment of rheumatoid arthritis in 1949, GC therapy has been associated with a number of adverse effects. Long-term use of GCs can result in growth retardation during childhood due to their actions on growth plate chondrocytes, although the …
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The molecular genetic investigation of paediatric liver disease
Liver disease in children is rare but often serious, life long, and in many cases leads to death. Advances in diagnosing and treating liver disease (including liver transplant) have improved the outlook for children in many cases however little is known about the molecular pathogenesis of the …
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An investigation of the Ciliary Protein PKHD1 in Cyst development in liver disease: clues to the pathogenesis of Biliary Atresia
Biliary atresia is a common form of paediatric liver disease, with progressive, inflammatory obliteration of the biliary tree, leading to liver failure early in life. Mutations in PKHD1, encoding the ciliary protein fibrocystin, are associated with autosomal recessive polycystic kidney disease …
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The role of Thyroid hormone Transporters Monocarboxylate Transporter 10 (MCT10) and Monocarboxylate Transporter 8 (MCT8) in extravillous trophoblasts.
Thyroid hormones (TH) are important for fetal and placental development. Monocarboxylate transporters 8 and 10 (MCT8, MCT10) are effective plasma membrane TH transporters expressed in the human placenta from 6 weeks of gestation. Both have been localized to human villous trophoblasts and …
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The dietary management of phenylketonuria
A wider understanding of the impact of each of the dietary components on blood phenylalanine concentrations in PKU may lead to improvements in management. Knowledge of the effects of such rigorous diet therapy on feeding behaviour is also important. In a series of studies, the effect of a number of …
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Infant feeding : an investigation into costs and practices
Numerous studies have shown the benefits of breastfeeding, however, the incidence and duration of breastfeeding in the UK is low and static, and breastfeeding rates in Liverpool in the North West of the UK are even lower. Breastfeeding is frequently promoted as being free yet little research has …
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Studies of the nutritional quality of commercial ‘ready to eat‘ infant foods in the United Kingdom
Infancy is a time of rapid physiological (e.g. anthropometric, immunological and neurological) development. Hence, during this period of life nutritional requirements are at their highest in relation to body mass. There is a paucity of data with respect to the nutritional quality of complementary …
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