Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RIPK1"”.
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Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
… Key regulators in the TLR4 pathway are RIPK1 and RIPK3, which are essential during programmed cell death, and therefore, signalling via TLR4 is key in the decision between pro immunity or cell death during infection. Whilst much is known about which molecules are involved in TLR4 …
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Analysis of drug resistance and the role of the stem cell niche in leukaemia
… CM reduced caspase-3/8 activation, downregulated RIPK1 (necroptotic marker), and limited chemotherapy-induced BECN1 downregulation, suggesting protective effects of CM. Glucocorticoids upregulated BIRC3 (which ubiquitinates RIPK1), whilst CM altered GR phosphorylation. GR occupancy was observed on …
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
… receptor-interacting protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage kinase domain-like protein (MLKL). Phosphorylation of human RIPK3 at serine 227 (S227) has been shown to be required for downstream MLKL binding and necroptosis progression. Tandem immunoprecipitation of RIPK3 reveals …
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Exploring The Relationship Between Mitochondrial-linked Cell Death And Muscle Atrophy During Ovarian Cancer Progression
… and remained high, while necroptosis markers (RIPK1, phosphorylated MLKL/total MLKL) decreased with cancer progression. EOC-induced changes in necroptosis were unaffected by SkQ1, whereas markers of apoptosis (caspase-3/-9 activities) were downregulated by SkQ1. This study lays a crucial …
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Calpain 9 Functions in TNF Receptor Mediated Apoptosis
… TNF-a induced apoptosis. CAPN9 is essential for RIPK1 recruitment and ubiquitination at the TNFR1 upon activation with TNF-alpha. CAPN9 knockdown demonstrates previously unreported association of ubiquitinated proteins, and actin binding proteins with TNFR1 in the absence of stimulus. This …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… cell death was subsequently determined to be RIPK1-dependent necroptosis, which was reversed by inhibition of RIPK1 by necrostatin-1. BCL-XL may directly inhibit necroptosis induction at the level of the necrosome through the binding of the effector protein MLKL, which was displaced upon …
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Rôle de RIPK3 dans la mort induite par la thérapie photodynamique
… induite en présence de RIPK3 était dépendante de RIPK1 au contraire de la nécrose induite dans les cellules U2OS RIP3 négatives. L’expression de RIPK3 a induit un changement de profil de la mort induite par 5-ALA-PDT, mais aussi une meilleure survie cellulaire face à ce traitement. Cet …
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… cytoplasmic death-inducing complex consisting of RIPK1, FADD and procaspase-8. Procaspase-8 undergoes homodimerization within this complex and subsequently activates effector caspases-3 and -7 to promote apoptosis. FLIP, a pseudo-caspase, can also bind to FADD and inhibit homodimerization of …
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Caspase isoforms in inflammasome activation
… caspase-8 genes identified an essential role for RIPK1 in pro-IL-1β priming, and potentially, for caspase-8 in IL-1β maturation. The characterisation of caspase functionality in dog and DogMo cells show marked differences despite their expression of a similar protein. The deficit in inflammasome …