Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"RIP3"”.
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RIP3 Marker Expression for Necroptosis in Cases of Prostate Cancer // Експресия на маркер за некроптоза RIP3 в случаи на простатен карцином
… и оцени експресията на маркера за некроптоза RIP3 в туморната тъкан на простатен карцином във връзка с клинико-патологичните показатели и да се определи прогностичната му и предиктивна стойност за преживяемостта на пациентите. За тази цел се анализираха заболеваемостта и смъртността от …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
Receptor-interacting protein kinase 3 (RIP3 or RIPK3) is a central player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… kinase receptor interaction protein 3 (RIP3, as promoter for RCD) in two different systems.</p> <p>First, I studied the role of PD-1 signaling in the cytotoxicity of natural killer (NK) cells. In recent years, PD-1 has become a hot target of immunotherapy. However, because most studies …
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
… serine/threonine-protein kinase-3 (RIP3), a key enzyme in the necroptosis pathway was crucial in determining susceptibility to this mode of death. Although an <em>in vitro</em> screen revealed that many HNSCC cell lines were resistant to necroptosis due to low levels of RIP3, patient …
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Expression of Markers for Autophagy and Necroptosis in Colorectal Carcinoma // Експресия на маркери за автофагия и некроптоза при дебелочревен карцином
… за автофагия – Beclin-1 и за некроптоза – RIP3 във връзка с клинико-патологичните показатели и общата преживяeмост при пациенти с КРК. В настоящото проучване са включени общо 107 пациенти с диагноза аденокарцином на дебело черво. Диагнозата и стадият на тумора са потвърдени според 7-мо …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
… form the core of the necrosome complex. RIP3-dependent phosphorylation of MLKL promotes the formation of high molecular weight MLKL polymers that disrupt the integrity of the plasma membrane leading to cell death. However, the mechanistic details of MLKL polymerization and its precise …
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Rôle de RIPK3 dans la mort induite par la thérapie photodynamique
… de la nécrose induite dans les cellules U2OS RIP3 négatives. L’expression de RIPK3 a induit un changement de profil de la mort induite par 5-ALA-PDT, mais aussi une meilleure survie cellulaire face à ce traitement. Cet accroissement de la survie, dont l’observation constitue une première …
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Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin
… super-low dose LPS was able to activate RIP3, a kinase responsible for inducing the inflammatory cell death, necroptosis. These mechanisms were regulated in an Interleukin-1 receptor-associated kinase 1 (IRAK-1) dependent manner. In the second study, the molecular mechanisms governing the …
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The anti-cancer activity of extracts derived from millets and Kraalbos
… 8, and 9 and PARP) and necroptosis (p-MLKL and p-RIP3) KB2 was found to induce cell death via the intrinsic and extrinsic apoptotic pathways and necroptosis. Western blotting and immunocytochemistry with an antibody to LC-3 also showed that KB2 induces autophagy in the breast cancer cells but …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… -9. Increased levels of necroptotic markers p-RIP3 and p-MLKL and inhibition of necroptosis with necrostatin-1 with a corresponding significant increase in cell viability suggests that AJ-5 is also capable of triggering a form of programmed necrosis. Furthermore, AJ-5 reduced autophagic flux as …