Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"RIP2"”.
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Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis
… (103 CFUs/mouse). We observed that NOD2/RIP2 signaling is critical for the host defense during gram-negative pneumonia and poly microbial sepsis. The NOD2/RIP2 axis regulates neutrophil recruitment via IL-17A production. We also found that NOD2/RIP-2 signaling is essential for the …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
… complex while receptor-interacting protein 2 (Rip2) is a positive upstream regulator of NF-kB pathway. In my PhD projects, I sought to investigate if RPS3 and Rip2 siRNA could protect against HDM-induced mouse asthma model or CS-induced mouse COPD model. RPS3 and Rip2 siRNA markedly knocked …
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Characterisation of a novel interaction partner for Atg16L1 and its role in regulating autophagy
… by binding the downstream adaptor protein RIP2, leading to the hypothesis that MEKK4 may play a role in autophagy. The interaction was verified by co-immunoprecipitation, with domain analysis indicating that MEKK4 binds to the linker region of Atg16L1. The kinase activity of MEKK4 was also …