Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RIP1"”.
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Cloning and characterization of RIP1, an effector of Ral
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… ofTRAF2, FADD, caspase-8, caspase-10 and RIP1 in JNK activation were examined. It was found that JNK is activated in HCT116, but not in DR5, caspase-8 and FADD knockdown cells after 5-FU treatment. Moreover, the absence of caspase-10, TRAF2 and RIP1 does not affect JNK activation.Also it …
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The Paradoxical Roles of Cell Death Pathways in Immune Cells
… work, I delve into the specific regulation of Rip1 kinase and demonstrate that in addition to previously demonstrated regulation by caspase-8, cathepsins are also able to cleave Rip1 kinase and limit necroptosis. This thesis presents a wide variety of novel data regarding the regulation of cell …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… lipid and glucose metabolism, mitochondrial, and RIP1 binding to influence cell survival and death. Despite previous studies performed in the Nik-/- model, the mechanisms underlying eosinophil development, plasticity, and fitness in conjunction with the bone marrow and splenic microenvironments …
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Investigating the Role of Pellin03 in TNF Signalling
… directly interacts with DISC components, RIP1 and caspase-8, but not FADD. Furthermore we show that Pellino3 regulates the formation of DISC and apoptosis in a manner that is dependent on the FHA domain but independent of the RING-like domain of Pellino3. The physiological importance of …
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Determining the mechanism of double-stranded RNA-induced cell death in ovarian cancer.
… cell lines, increased c-IAP2 levels and RIP1 kinase ubiquitination occurred, as well as, an increase in basal level autophagy with dsRNA stimulation. However, individual blockade of these pathways did not restore dsRNA-induced apoptosis. In a non-responsive cell line, dsRNA enhanced the …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
… pathway have been discovered including RIP1/3 kinases and MLKL, which together, form the core of the necrosome complex. RIP3-dependent phosphorylation of MLKL promotes the formation of high molecular weight MLKL polymers that disrupt the integrity of the plasma membrane leading to cell …
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Investigating the regulation and enzymatic function of human ecsit in innate immune signalling.
… regulate the ubiquitination of TRAF6, TRAF3 and RIP1 in TLR4/IL-1R, TLR3 and TNF-α signalling, respectively. These findings identify hECSIT as a novel regulator of innate immune signalling and highlight a sophisticated evolutionary difference between two highly conserved proteins.
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
<p>Caspase-8 (CASP8) is one of the most frequently mutated genes in Head and Neck Squamous Carcinomas (HNSCC), and mutations of CASP8 are associated with poor overall survival. The distribution of these mutations in HNSCC suggests that they are likely to be inactivating. Inhibition of CASP8 has …