Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"RING finger domain"”.
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Investigation of Interaction between heat shock protein 70.14 (Hsp 70.14) and RBBP6 RING finger domain
… is an Hsp70 variant that lacks the c-terminal domain but contains substrate binding domain and the ATPase domain. The postulated interaction of this protein with the RING finger domain of RBBP6, suggested their role in protein quality control system and chaperone-mediated ubiquitination. …
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Recombinant expression, purification and structural characterization of aspergillus niger ring finger domain using nuclear magnetic resonance spectroscopy
… protein which contains an N-terminal DWNN domain and a conserved RING finger domain. Previous studies determined the solution structure of the human RING finger domain using heteronuclear NMR spectroscopy. A bioinformatics analysis using the human RING finger from RBBP6 as searching bait …
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Recombinant expression, purification and structural characterization of Saccharomyces cerevisiae RING finger domain using Nuclear Magnetic Resonance (NMR) spectroscopy
RING finger domain is a domain that is incorporated with other domains to form a large protein known as RBBP6. This is a 250kDa protein that stands for Retinoblastoma binding domain protein 6. It is classified according to different homologues namely RBQ1, PACT, SNAMA, Mpe-1 and P2P-R depending on …
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Biophysical investigations of the interaction between substrate binding domain of Hsp40 and the RING finger domain of Retinoblastoma Binding Protein 6
… disease. Through a yeast-two hybrid study, the RING finger domain of the Retinoblastoma binding protein 6 (RBBP6) and the substrate binding domain of heat shock protein 40 (SBDHsp40) suggested a putative interaction between these two proteins. In this study molecular dynamic simulations were …
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Analysis of the biophysical and in silico exploration of the interaction between small ribonucleoprotein G and the RING finger domain of retinoblastoma binding protein 6 for the identification of protein anti-cancer compounds
… and interaction patterns of SNRPG with the RBBP6 RING Finger domain with a docking score of 3.40kcal/mol. Using I-TASSER, a potential inhibitor known as (2R)-2-[(2-methyl-5-phenylpyrazol-3-yl) carbonyl amino]-3-napthalen-2-yl-propanoic acid) (4FI) was identified and MM/GBSA binding free energy …
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ScRING finger protein, Mdm2, MdmX, p53, cancer, ubiquitination, drug discovery, ZINC16046951, University of Zululand, South Africa
… and Dranoff, 2012). Really Interesting New Gene (RING) finger protein is a truncated domain from RBBP6 known to function independently in protein-protein interaction and cellular processing signalling. It is a 10 kDa protein defined by its hallmark residues cysteine and histidine that binds two …
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A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
… partners of RBBP6, two well characterized domains of RBBP6, the N-terminal ubiquitin-like DWNN domain and RING finger domain, were used as baits in a yeast 2-hybrid screen of a human testis cDNA library. Putative interactors were verified using in vitro and in vivo immunoprecipitation …
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PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
… with cellular proteasomes. ICP0 has a RING finger domain with E3 ubiquitin ligase activity that is necessary for its IE functions. The fundamental and functional properties of ICP0 that is present in the virion tegument layer have not been well characterized. For these reasons, I sought …
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Genetic analysis of programmed cell death in Drosophila melanogaster
… In addition, our mutants indicate that Diapl's RING finger domain, a domain found in proteins that function in ubiquitination, is required for inhibition of Rpr- and Grim-induced death but not Hid-induced death.
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Functional Analysis of KAP1 Requirements for HIV-1 Transcription and Latency Reactivation
… is on target. By combining comprehensive KAP1 domain deletion and mutagenesis in a cell-based reporter assay, I genetically defined the RING finger domain and an Intrinsically Disordered Region as key activating features. However, KAP1 acute loss in a physiological relevant model, reveals …
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Disruption of UHRF1 expression in chicken DT40 cells
… regulators, UHRF1 (ubiquitin-like with PHD and ring finger domain containing protein 1) has attracted considerable attentions in cancer research in past years due to its universally increased expression in a wide range of different cancer cells, and its ability to facilitate the crosstalk …
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B-box Proteins in Light-regulated Development in Arabidopsis
… N-terminal B-boxes. B-boxes are zinc-ligating domains consisting of conserved cysteine and histidine residues. In animals, B-boxes are often found together with a RING finger domain (originally termed A-box) and a coiled-coil domain forming RBCC or tripartite motif (TRIM) proteins. Although …